Pitolisant shows promise for Long-Term control of idiopathic hypersomnia
NCT ID NCT05458128
First seen Jan 06, 2026 · Last updated Jun 23, 2026 · Updated 30 times
Summary
This study looks at the long-term safety and effectiveness of pitolisant in adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness. Participants had already completed a previous study. The goal is to see if pitolisant remains safe and helps control symptoms over time.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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ARSM Research
Huntersville, North Carolina, 28078, United States
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Abington Neurological Associates
Willow Grove, Pennsylvania, 19090, United States
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Bogan Sleep Consultants
Columbia, South Carolina, 29201, United States
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Cedars-Sinai Medical Towers
Los Angeles, California, 90048, United States
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Central Texas Neurology Consultants, PA
Round Rock, Texas, 78681, United States
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Clayton Sleep Institute
St Louis, Missouri, 63123, United States
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Clinical Neurophysiology Services
Sterling Heights, Michigan, 48314, United States
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Clinical Research of Gastonia
Gastonia, North Carolina, 28054, United States
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Comprehensive Sleep Medicine Associates
Sugar Land, Texas, 77478, United States
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Duke University School of Medicine
Durham, North Carolina, 27705, United States
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Florida Pediatric Research Institute
Winter Park, Florida, 32789, United States
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FutureSearch Trials of Neurology LP
Austin, Texas, 78731, United States
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Great Plains Health
North Platte, Nebraska, 69101, United States
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Intrepid Research, LLC
Cincinnati, Ohio, 45245, United States
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Lowcountry Lung Critical Care
North Charleston, South Carolina, 29406, United States
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Meris Clinical Research
Brandon, Florida, 33511, United States
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NeuroScience Research Center, LLC
Canton, Ohio, 44718, United States
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Neurology Clinic, P.C.
Cordova, Tennessee, 38018, United States
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Neurotrials Research Inc.
Atlanta, Georgia, 30328, United States
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North Star Medical Research
Middleburg, Ohio, 44130, United States
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NorthShore University Health System
Glenview, Illinois, 60026, United States
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Northwell Health
New Hyde Park, New York, 11042, United States
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Northwest Houston Neurology and Sleep
Tomball, Texas, 77375, United States
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OSF HealthCare Saint Francis Medical Center
Peoria, Illinois, 61637, United States
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Ohio Sleep Medicine and Neuroscience Institue
Dublin, Ohio, 43017, United States
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Respiratory Specialists
Wyomissing, Pennsylvania, 19610, United States
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Sleep Dynamics
Neptune City, New Jersey, 07753, United States
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Sleep Medicine Specialists of California
San Ramon, California, 94583, United States
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St. Francis Medical Institute
Clearwater, Florida, 33765, United States
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St. Luke's Sleep Medicine and Research Center
Chesterfield, Missouri, 63017, United States
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University of Wisconsin-Madison
Madison, Wisconsin, 53719, United States
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Western Michigan University Homer Stryker MD School of Medicine
Kalamazoo, Michigan, 49008, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pitolisant
What this could lead to
If successful, this could confirm pitolisant as a safe long-term treatment to reduce excessive daytime sleepiness and other symptoms of idiopathic hypersomnia.
What could go wrong
This is an open-label study with no placebo group, so results may be less reliable. Side effects are possible, and long-term benefits are not guaranteed.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.