Hypoxemia

This trial is testing a new ventilator called INBENTUS VERSATILE in 81 adults who need help breathing. The study checks if the device is safe and works well for conditions like ARDS, pneumonia, and COPD. Participants will use the ventilator for 3 to 48 hours and be monitored unti…

This phase 2 trial is testing whether an inhaled drug called treprostinil (Tyvaso) can improve oxygen delivery in the lungs of people with COPD who have low blood oxygen. Ten adults will use the nebulizer four times daily for four weeks, starting at a low dose and increasing as t…

This study tests a medical device called PIMUN to see if it can reduce the time preterm babies spend with low oxygen levels. About 20 infants born before 34 weeks who have apnea of prematurity will be randomly assigned to use the device for 48 hours or receive usual care. Researc…

Researchers at the University of North Carolina are testing a new pulse oximeter, called MABOS, that uses multiple wavelengths of light to estimate blood oxygen levels. Standard pulse oximeters can be less accurate on darker skin, which may lead to missed low oxygen levels in cri…

This study compares two oxygen delivery devices—high-flow nasal cannula and Microstream Advance nasal cannula—during ERCP, a procedure done under deep sedation. The goal is to see which one better prevents oxygen desaturation. 74 adults scheduled for ERCP will be randomly assigne…

This study tests whether using a breathing mask (positive airway pressure) or a special carbon dioxide monitor (capnometry) during ERCP can reduce the number of times patients' oxygen levels drop dangerously low. About 288 adults having ERCP with sedation will be randomly assigne…

This study tests whether a new device that combines a bite block, oxygen tube, and airway support can prevent dangerously low oxygen levels in severely obese patients during sedated endoscopy. About 410 adults with a BMI of 35 or higher will be randomly assigned to receive either…

This study compares two ways of giving oxygen during sedation for medical procedures done outside the operating room: high-flow nasal oxygen and a standard face mask. Researchers measure brain oxygen levels continuously to see which method keeps the brain better oxygenated. One h…

This research project looks at how medical oxygen and pulse oximetry (a device that measures oxygen levels in the blood) are used in hospitals in several countries. The goal is to understand what helps or hinders the effective use of oxygen, especially for children with condition…

This study looks at whether giving extra oxygen during a 6-minute walk test helps people with chronic lung disease walk farther and feel better. About 114 adults with conditions like COPD or interstitial lung disease will do two walking tests—one with their usual oxygen and one w…

This study looks at whether pulse oximeters—the clips placed on fingers to measure oxygen levels—work equally well for children with different skin tones who have congenital heart disease. Researchers will enroll 92 children under 18 undergoing heart surgery and compare the oxime…

This study looks at how medical oxygen programs work in six countries across Africa and Asia. Researchers will interview policymakers, health workers, and others to find out what helps or hinders oxygen access. The goal is to improve national and global policies, not to test a ne…