HYPOPARATHYROIDISM

This study tests an experimental mRNA drug called XH-02 in 60 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone (PTH). The drug is designed to help the body produce PTH, which controls calcium levels. Researchers want to see if it …

This early-stage study tests whether transplanting donated parathyroid tissue into the forearm can help people with hypoparathyroidism achieve normal calcium and phosphorus levels. Three adults who have low parathyroid hormone after surgery will receive the transplant and take li…

This early-stage trial tests an mRNA drug called XH-02 in 15 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone (PTH). The drug is injected under the skin to help replace the missing hormone. The main goal is to check safety, while also measuring…

This study tests a daily injection of palopegteriparatide at doses above 30 mcg in adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. The goal is to see if higher doses can safely control calcium levels without needing extra vitami…

This early-stage study tests a new mRNA drug (XH02) that helps the body produce parathyroid hormone (PTH), which is missing in people with hypoparathyroidism. The goal is to see if it is safe and can restore normal calcium and phosphorus levels. Six adults aged 18 to 65 with chro…

This study tests a new drug called AMOR-1 in 81 adults with hypoparathyroidism, a condition where the body can't control calcium levels. The goal is to see if AMOR-1 can safely lower the amount of calcium supplements people need to take. Participants will be randomly assigned to …

This study is a pregnancy registry that collects information from women who took YORVIPATH for hypoparathyroidism around the time of pregnancy or while breastfeeding. Researchers will follow about 50 women and their babies for at least a year to watch for complications, birth def…

This study follows 106 adults with hypoparathyroidism for three years to see how the disease affects organs like the kidneys and brain. No new treatments are tested; instead, researchers monitor changes through blood tests and optional CT scans. The goal is to better understand t…

This study aims to make sure lab tests, equipment, and procedures used in research on obesity, diabetes, heart disease, and bone disorders are accurate and give consistent results. It will involve up to 100 healthy volunteers and people with these conditions, aged 18 to 100. The …

This study looks at how much of the drug palopegteriparatide (YORVIPATH) passes into breast milk. It involves 10 lactating women with hypoparathyroidism who are already taking the drug and choose to breastfeed. Researchers will collect milk samples to measure drug levels, helping…