HERPES ZOSTER

This study looks at how well the Shingrix vaccine works and how safe it is for people with HIV, compared to healthy volunteers. About 225 adults will get two shots of the vaccine and be followed for a year. The goal is to see if the vaccine boosts immunity against shingles in peo…

This study is testing a new mRNA vaccine designed to prevent shingles (herpes zoster) in adults aged 40 and older. The trial has two parts: Part A checks safety and immune response in people 40+, and Part B picks the best dose and schedule for those 50+. Around 519 volunteers wil…

This study tests a new shingles vaccine called Z-1018 in about 764 healthy adults aged 50 and older. Researchers compare it to the current vaccine, Shingrix, to see if it is safe and triggers a strong immune response. The goal is to find a better way to prevent shingles, a painfu…

This study is testing a shingles vaccine in children aged 1 to 17 who have had a kidney transplant and have a weakened immune system. The goal is to see if the vaccine is safe and helps their bodies fight off shingles. Researchers will give two doses of the vaccine and watch for …

This study tests whether the oral medication Venlafaxine can prevent postherpetic neuralgia, a chronic nerve pain that often follows shingles. About 832 adults with moderate to severe shingles pain will receive Venlafaxine or a placebo to see if early treatment reduces the risk o…

This large study in Finland is testing whether the Shingrix vaccine, which prevents shingles, can also reduce the risk of developing dementia in adults aged 76 and older. About 33,600 participants will receive either the vaccine or a placebo and be monitored for new dementia diag…

This study compares two antiviral drugs, brivudine and famciclovir, in 140 adults with shingles. The main goal is to see which one reduces pain more effectively after 30 days. Researchers will also check how quickly skin lesions heal and whether long-term nerve pain (postherpetic…

This study tests whether adding a newer pain medicine called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. Researchers will enroll 750 adults with moderate to severe shingles pain that started within the last 30 days. Partic…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study tests whether a flurbiprofen patch, applied to the skin, can safely reduce pain from shingles (herpes zoster). Shingles causes a painful rash, and current pain treatments often don't work well or have side effects. The trial will include 750 adults with moderate to sev…

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will apply the patch to the painful area. The goal is to see if the patch provides better pain relief than current treatment…

This study compares two treatments for long-term nerve pain after shingles (postherpetic neuralgia). Researchers will give 50 adults either a nerve block injection or a radiofrequency treatment to see which reduces pain more. The goal is to find a better way to ease this stubborn…

This study tests whether adding a new pain drug called crisugabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The g…

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study looks at how electroacupuncture (a type of acupuncture with mild electric pulses) changes immune cells in people with shingles. Researchers will compare patients who get standard medication alone versus medication plus electroacupuncture. The goal is to understand if e…