Healthy adult

This pilot study tests whether a daily dietary supplement called Diaplex can improve how the body handles blood sugar in healthy adults aged 30 to 65 who have mildly elevated glucose levels. Over 16 weeks, participants receive either Diaplex or a placebo, and researchers measure …

This early-stage study tests a new tablet called HS-10522 in healthy Chinese adults and those with mild hypertension. The main goal is to check safety and how the drug moves through the body. 88 participants will receive either the drug or a placebo to compare side effects and dr…

This study tests if taking probiotics can help healthy Chinese adults keep their gut bacteria balanced during a short trip to Europe. Forty participants will take either a probiotic or a placebo for 7 days. Researchers will check stool samples and ask about breathing symptoms to …

This study tests a new robot-based therapy designed to improve arm movement and sensation in people who had a stroke more than six months ago. The therapy focuses on helping the brain better process sensory information from the arm. The trial will include 109 participants and com…

This study looks at how urolithin A, a compound from the supplement Mitopure®, moves into the fluid around the brain. Forty healthy adults aged 18-45 will take the supplement, and researchers will measure its levels in their spinal fluid at different times. The goal is simply to …

Researchers are studying healthy adults who live above 2600 meters to see how their lungs respond when they descend to sea level for a week and then return to their usual altitude. The trial measures pulmonary resistance, which is how hard the heart must work to pump blood throug…

Researchers are studying what happens when people who live permanently above 2600 meters, such as in Quito, Ecuador, spend a week at sea level. They will measure lung blood pressure and other heart and lung functions in healthy adults and in patients with pulmonary arterial hyper…

This study follows healthy adults who live above 2600 meters as they descend to sea level for one week and then return to their usual altitude. Researchers measure lung function, blood oxygen, and sleep before, during, and after the trip. The goal is to see how the lungs respond …

This study looks at what happens when people who live above 2600 meters, in places like Quito, spend a week at sea level and then return to altitude. Researchers will measure sleep quality, oxygen levels during the night, and breathing patterns in healthy adults and in people wit…

Researchers are studying healthy adults who live permanently above 2600 meters, like in Quito, Ecuador. They will travel by bus to sea level for one week, then return to high altitude. The study measures heart rate variability, blood oxygen levels, and sleep patterns during the d…

This study looks at what happens when healthy people who live above 2600 meters, such as in Quito, Ecuador, spend a week at sea level. Researchers will measure walking distance, oxygen levels, and other health markers before and after the descent. The goal is to understand how th…

Researchers are testing whether one intense aerobic exercise session, done until exhaustion, alters levels of four proteins in saliva: irisin, klotho, sirtuin-1, and BDNF. These proteins are linked to metabolism, aging, and brain function. The study enrolls healthy adults aged 18…

This study tests whether polyphenols from whole grapes can improve metabolic flexibility, the body's ability to shift between burning carbohydrates and fat after a meal. Researchers will give 20 adults, half lean and half with overweight or obesity, a single dose of grape powder …

This study looks at what happens when healthy people who live above 2600 meters spend a week at sea level and then return to their high-altitude home. Researchers measure walking distance, oxygen levels, and heart rate before and after the re-ascent. The goal is to understand how…

This trial tests whether eplerenone, a drug already approved for other conditions, lowers eye pressure in healthy adults. Researchers will compare eplerenone with a placebo in a crossover design, where each participant takes both treatments at different times. Eye pressure is mea…

This study looks at whether teaching East Asian American adults about alcohol flushing and offering them a genetic test for it is practical and helpful. About 100 people who flush when they drink or have a family history of flushing will take part. Half will get education only, a…

This early-stage trial is testing an experimental drug called XKH001 in healthy Caucasian adults. The drug is an antibody designed to block a protein involved in allergic and inflammatory responses. The study aims to see how the body processes the drug, whether it is safe and wel…

This study tests whether ivabradine, a medication that slows heart rate without weakening the heart's pumping strength, can help researchers understand how heart rate limits exercise capacity. Healthy younger and older adults will take a single dose of ivabradine before cycling t…

This study compares two types of hamstring training—eccentric exercises like the Romanian deadlift and Nordic hamstring exercise versus sprint-specific drills—in healthy collegiate athletes. Over 10 weeks, researchers measure changes in muscle size, strength, power, and sprint pe…

This study looks at whether exercising at an unexpected time of day affects leg strength and performance. Healthy adults aged 18-25 who usually exercise at the same time each day will be asked to work out three hours earlier or later than normal. Researchers will measure their le…

This trial investigates whether the common flavor enhancer monosodium glutamate (MSG) increases blood levels of imidazole propionate (ImP), a compound produced by gut bacteria from the amino acid histidine. Higher ImP levels have been linked to blood-sugar control issues. Healthy…

This study compares two ways of inviting people to screen for type 1 diabetes at home: a simple email or letter versus a personal phone call. Researchers want to see which method leads more people to complete and return a home screening kit. Participants are adults and children a…

This observational study will examine whether ultrasound images of muscles can predict strength in 300 healthy adults aged 18 to 89. Participants will have ultrasound scans of their thigh and forearm muscles, plus strength tests and questionnaires. The goal is to find simple, non…

This study looks at how safe and effective an 8-week strength training program is when combined with blood flow restriction (BFR) — a technique that partially limits blood flow to the working muscles. Sixty healthy, untrained adults aged 18 to 65 will be randomly assigned to one …

This study compares foam rolling and therapeutic massage to see which is better at relaxing calf muscles. Twenty healthy adults will try both techniques, and researchers will measure muscle tone, stiffness, and elasticity. The goal is to find out if a simple foam roller can work …

This study looks at how a non-invasive brain stimulation technique called rTMS affects two different areas of the cerebellum in 40 healthy adults. One area is linked to movement, the other to thinking and attention. By comparing the effects, researchers hope to learn which brain …

This early-stage trial will give a single inhaled dose of GH001 (5-MeO-DMT) to 12 healthy adults. Researchers will measure how the drug moves through the body and check for any side effects. The goal is to gather basic safety information needed before testing the drug in people w…

This phase 1 trial will test the safety and tolerability of a drug called CIT-013 in 10 healthy adults. Participants receive either CIT-013 or a placebo by injection under the skin. The study is double-blind, meaning neither participants nor researchers know who gets the real dru…

This study looks at whether aerobic exercise (like cycling) changes how sensitive people are to pressure pain, and if this effect differs between men and women. Researchers will measure pain thresholds in 30 healthy adults before, right after, and 30 minutes after exercise. The g…

This early-stage study tests a new liposome-based antidote in 12 healthy adults aged 18-30. The goal is to check safety and how the body processes the drug, not to treat any disease. Participants must be in good health and avoid pregnancy during the study.

This study tests whether a special ultrasound technique called shear wave elastography can measure how hard someone is working to breathe. Currently, doctors must insert a balloon-tube into the esophagus to measure breathing effort, which is uncomfortable. Researchers will compar…

This early-phase trial will test the safety and how the body handles a single dose of DW5524 in 48 healthy adults. Participants will be randomly assigned to receive either DW5524 or a related version, DW5524-A. The study aims to understand the drug's effects and how it moves thro…

This study aims to see if a new heart ultrasound technique, called myocardial work, can predict which patients will respond to cardiac resynchronization therapy (CRT) for heart failure. Researchers will also establish normal heart ultrasound values in healthy Chinese adults. The …