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New ultrasound method may predict heart failure treatment success

NCT ID NCT07319065

Knowledge-focused Sponsor: First Hospital of China Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to see if a new heart ultrasound technique, called myocardial work, can predict which patients will respond to cardiac resynchronization therapy (CRT) for heart failure. Researchers will also establish normal heart ultrasound values in healthy Chinese adults. The study plans to enroll over 3,000 participants across multiple centers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better predict which heart failure patients will respond to cardiac resynchronization therapy, reducing the number of non-responders.
What could go wrong
This is an observational study that only measures heart function; it does not test a new treatment. The findings may not apply to all ethnic groups or heart failure patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 3,240 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study enrolls 4 groups (18-79 years) from clinics/community: Healthy Adults: Han Chinese with normal cardiovascular function (vitals, labs, ECG, echo; no structural heart disease/systemic diseases/poor ultrasound). Heart failure patients with LBBB who are scheduled for CRT treatment： LVEF ≤ 35%,QRS ≥ 150ms; LBBB.At least 3 months of optimal drug therapy before implantation. Patients with LBBB who have preserved LVEF :LVEF≥53%, LBBB. Patients with reduced LVEF but without LBBB :LVEF ≤ 35%,non-LBBB.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Healthy Adults Group Inclusion Criteria: * Participants must meet all of the following criteria to be enrolled: 1. Of Han Chinese ethnicity 2. Aged 18-79 years 3. Normal blood pressure (\< 140/90 mmHg) 4. Normal fasting blood glucose 5. Normal blood lipid levels (triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein) 6. Normal complete blood count results (hemoglobin concentration, white blood cell count, red blood cell count, platelet count) 7. Normal liver and renal function (alanine transaminase \< 2× upper limit of normal; normal creatinine and blood urea nitrogen) 8. Normal electrocardiogram results (occasional atrial premature beats may be enrolled at the investigator's discretion) 9. No structural heart disease and normal cardiac function confirmed by echocardiography Exclusion Criteria: Participants will be excluded if they meet any of the following criteria: 1. Clinically significant cardiac valve regurgitation (≥ mild severity) 2. Respiratory diseases: acute or chronic respiratory disorders 3. Endocrine diseases: thyroid disease, diabetes mellitus, hyperaldosteronism, pheochromocytoma, etc. 4. Abnormal liver function (alanine transaminase \> 2× upper limit of normal), abnormal renal function (elevated creatinine beyond normal range), or dyslipidemia (elevated triglycerides, total cholesterol, low-density lipoprotein, or high-density lipoprotein) 5. Other systemic diseases: anemia, malignancy, connective tissue disease, large artery/peripheral vascular diseases (aortic dilation, aortic dissection, coarctation of the aorta, Takayasu arteritis, atherosclerosis), etc. 6. Pregnant or lactating women 7. Professional athletes 8. Poor-quality ultrasound images that cannot support parameter measurement and analysis Heart failure patients with LBBB who are scheduled for CRT treatment Group Inclusion criteria: 1. LVEF ≤ 35% 2. QRS ≥ 150ms; LBBB 3. At least 3 months of optimal drug therapy before implantation Exclusion Criteria: 1. Suffering from connective tissue diseases such as systemic lupus erythematosus, polymyositis, and rheumatoid arthritis; 2. Having a history of blood diseases and severe systemic diseases such as infections; 3. Those who cannot cooperate with the examinations. Patients with LBBB who have preserved LVEF Group Inclusion criteria: 1. LVEF≥53% 2. LBBB Exclusion Criteria: 1. Suffering from connective tissue diseases such as systemic lupus erythematosus, polymyositis, and rheumatoid arthritis; 2. Having a history of blood diseases and severe systemic diseases such as infections; 3. Those who cannot cooperate with the examinations. Patients with reduced LVEF but without LBBB Group Inclusion criteria: 1. LVEF ≤ 35% 2. non-LBBB Exclusion Criteria: 1. Suffering from connective tissue diseases such as systemic lupus erythematosus, polymyositis, and rheumatoid arthritis; 2. Having a history of blood diseases and severe systemic diseases such as infections; 3. Those who cannot cooperate with the examinations.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CRT non-response Healthy adult HF - heart failure LBBB

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    82 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of North Sichuan Medical College

    Nanchong, Sichuan, China

  • Anhui University of Chinese Medicine First Affiliated Hospital

    Hefei, Anhui, China

  • Bethea Hospital of Shanxi Province

    Taiyuan, Shanxi, China

  • Central Hospital of Anshan City

    Anshan, Liaoning, China

  • Changzhou Second People's Hospital

    Changzhou, Jiangsu, China

  • Chifeng Hospital

    Chifeng, Neimenggu, China

  • Dianxi Central Hospital of Yunnan Province

    Dingxi, Yunnan, China

  • Enshi Central Hospital

    Enshi, Hubei, China

  • FuWai Central China Cardiovascular Hospital

    Zhengzhou, Henan, China

  • Fujian Provincial Geriatric Hospital

    Guizhou, Fujian, China

  • Gansu Provincial People's Hospital

    Lanzhou, Gansu, China

  • Guizhou Provincial People's Hospital

    Guizhou, Fujian, China

  • Jiangmen Central Hospital

    Jiangmen, Guangdong, China

  • Jiangsu Provincial People's Hospital

    Nanjing, Jiangsu, China

  • Jinan Central Hospital

    Jinan, Shandong, China

  • Liaoning Golden Autumn Hospital

    Shenyang, Liaoning, China

  • Lihuili Hospital of Ningbo Medical Center

    Ningbo, Zhejiang, China

  • Longnan Hospital of Daqing Oilfield General Hospital

    Daqing, Heilongjiang, China

  • Puai Hospital of Wuhan City / The Fourth Hospital of Wuhan City

    Wuhan, Hubei, China

  • Shanghai Chest Hospital

    Shanghai, China

  • Shanxi Cardiovascular Hospital (Shanxi Cardiovascular Hospital Research Institute)

    Taiyuan, Shanxi, China

  • Shengjing Hospital, China Medical University

    Shenyang, Liaoning, China

  • Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University

    Hangzhou, Zhejiang, China

  • Su Bei People's Hospital

    Yangzhou, Jiangsu, China

  • Suqian Hospital of Jiangsu Provincial People's Hospital

    Suqian, Jiangsu, China

  • Taizhou Hospital of Zhejiang Province

    Taizhou, Zhejiang, China

  • Tangdu Hospital, Air Force Medical University

    Xi’an, Shanxi, China

  • The Affiliated Hospital of Jiangnan University

    Wuxi, Jiangsu, China

  • The Affiliated Hospital of Qingdao University

    Qingdao, Shandong, China

  • The Cancer Hospital of Shanxi Province

    Taiyuan, Shanxi, China

  • The First Affiliated Hospital of Anhui Medical University

    Hefei, Anhui, China

  • The First Affiliated Hospital of Chongqing Medical University

    Chongqing, China

  • The First Affiliated Hospital of Dalian Medical University

    Dalian, Liaoning, China

  • The First Affiliated Hospital of Guizhou Medical University

    Guizhoucun, Jiangxi, China

  • The First Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, China

  • The First Affiliated Hospital of Henan Medical University (Xinxiang Medical University)

    Zhengzhou, Henan, China

  • The First Affiliated Hospital of Henan University of Chinese Medicine

    Zhengzhou, Henan, China

  • The First Affiliated Hospital of Kunming Medical University

    Kunming, Yunnan, China

  • The First Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, China

  • The First Affiliated Hospital of Ningbo University

    Ningbo, Zhejiang, China

  • The First Affiliated Hospital of Shandong First Medical University

    Jinan, Shandong, China

  • The First Affiliated Hospital of Wannan Medical College

    Wannan, Anhui, China

  • The First Affiliated Hospital of Wenzhou Medical University

    Wenzhou, Zhejiang, China

  • The First Affiliated Hospital of Xiamen University

    Xiamen, Fujian, China

  • The First Affiliated Hospital of Xinjiang Medical University

    Xinjiang, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Heinan, China

  • The First Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • The First Hospital of China Medical University

    Shenyang, Liaoning, 110000, China

  • The First Hospital of Hebei Medical University

    Shijiazhuang, Hebei, China

  • The First Hospital of Jilin University

    Jilin City, Jilin, China

  • The First Hospital of Peking University

    Beijing, China

  • The First Hospital of Qinhuangdao City

    Qinhuangdao, Hebei, China

  • The First People's Hospital of Lianyungang City

    Lianyungang, Jiangsu, China

  • The First People's Hospital of Nantong City

    Nantong, Jiangsu, China

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, China

  • The Hospital of Traditional Chinese Medicine of Suzhou City

    Suzhou, Jiangsu, China

  • The People's Hospital of Ningxia Hui Autonomous Region

    Yinchuan, Ningxia, China

  • The People's Hospital of Shanxi Province

    Taiyuan, Shanxi, China

  • The People's Hospital of Sichuan Province

    Chengdu, Sichuan, China

  • The People's Hospital of Wuxi City

    Wuxi, Jiangsu, China

  • The People's Hospital of Ya'an City

    Ya'an, Sichuan, China

  • The People's Hospital of Zhuji City

    Zhuji, Zhejiang, China

  • The Provincial Hospital Affiliated to Fuzhou University

    Fuzhou, Fujian, China

  • The Second Affiliated Hospital of Chongqing Medical University

    Chongqing, China

  • The Second Affiliated Hospital of Nanchang University

    Nanchang, Jiangxi, China

  • The Second Affiliated Hospital of Soochow University

    Suzhou, Jiangsu, China

  • The Second Affiliated Hospital of Xi'an Jiaotong University

    Xi’an, Shanxi, China

  • The Second Affiliated Hospital, Zhejiang University School of Medicine

    Hangzhou, Zhejiang, China

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, China

  • The Second Hospital of Jilin University

    Jilin City, Jilin, China

  • The Second Hospital of Ningbo City

    Ningbo, Zhejiang, China

  • The Second Hospital of Shaoxing City

    Shaoxing, Zhejiang, China

  • The Third Hospital of Hebei Medical University

    Shijiazhuang, Hebei, China

  • The Third People's Hospital of Nantong City

    Nantong, Jiangsu, China

  • Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology

    Wuhan, Hubei, China

  • Union Hospital Affiliated to Fujian Medical University

    Guizhou, Fujian, China

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, China

  • Xiangyang Hospital of Traditional Chinese Medicine, Hubei Province

    Xiangyang, Hubei, China

  • Xindu District People's Hospital of Chengdu City

    Chengdu, Sichuan, China

  • Xinjiang Uygur Autonomous Region Hospital of Traditional Chinese Medicine / The Fourth Affiliated Hospital of Xinjiang Medical University

    Xinjiang, Xinjiang, China

  • Yan'an Hospital of Kunming City

    Kunming, Yunnan, China

  • Zhongshan Hospital Affiliated to Xiamen University

    Xiamen, Fujian, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.