HCC

This study tests whether adding two immunotherapy drugs (durvalumab and tremelimumab) to a radiation bead treatment (Y-90 SIRT) can shrink liver tumors that cannot be surgically removed. About 55 adults with intermediate-stage liver cancer will receive the combination. The main g…

This study tests a combination of drugs (cabozantinib, ipilimumab, nivolumab) and a procedure called TACE in people with liver cancer that cannot be removed by surgery or treated with a transplant. The goal is to see if this approach can stop the cancer from growing for at least …

This early-stage study tests a new drug, enzelkitug, given alone or with standard immunotherapy drugs, in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check safety and find the right dose. About 450 adults with cancers like lung, …

This study tests a new drug combination (VRT106, camrelizumab, and apatinib) in about 66 adults with advanced liver cancer whose previous immunotherapy stopped working. The goal is to see if the combination can shrink tumors or slow disease progression. Participants will receive …

This study tests a new way to give radiation for liver cancer in just one session, using real-time MRI to guide the beam and adjust the plan on the spot. It aims to improve survival and reduce side effects. About 62 adults with liver cancer or liver metastases will take part.

This study is for people with liver cancer that cannot be surgically removed or treated with ablation and has not spread. It compares a standard treatment (chemoembolization) against a newer approach using tiny radioactive beads (yttrium-90) alone or combined with immunotherapy d…

This study tests a radiation treatment (Y90) to help grow the liver in people with liver cancer who need surgery but don't have enough healthy liver left. The goal is to make surgery possible and improve survival. About 104 participants will receive either standard or optimized Y…

This study tests whether treating donor livers with a special oxygen-rich cold fluid (HOPE) before transplant can help prevent liver cancer from coming back. About 220 adults with liver cancer and cirrhosis who are waiting for a liver transplant will take part. Half of the donate…

This study tests whether adding targeted radiation (SBRT) to standard immunotherapy (atezolizumab plus bevacizumab) can improve survival in people with advanced liver cancer that has spread into the main portal vein. About 40 adults with this aggressive condition will receive the…

This study tests whether adding targeted radiation (SBRT) to spots where liver cancer has started growing again can help patients continue benefiting from immunotherapy. About 30 adults with advanced liver cancer that has progressed in a few places while on first-line immunothera…

This study tests a new drug, FOG-001, in about 595 people with advanced solid tumors that have not responded to other treatments. The goal is to see if FOG-001 is safe and can shrink tumors or slow their growth. The trial focuses on several cancer types, including colorectal, pro…

This study looks at how certain genes increase the risk of liver cancer (hepatocellular carcinoma) in people with nonalcoholic fatty liver disease (NAFLD). Researchers will follow 500 adults aged 45-75 with NAFLD to understand how genetic factors and lifestyle interact. The goal …

This study tests a program called HCC Liver-Link designed to help Black patients with early-stage liver cancer get faster access to treatments like transplant or surgery. The program includes education, social support, and help navigating cancer care. Forty participants will be r…

This study looks at how a person's genes and their environment (like alcohol use) together increase the risk of developing liver cancer from alcohol-related liver disease. Researchers will study 1000 people to find new genetic variants linked to this cancer. The goal is to better…

This study looks at whether a special ultrasound (contrast-enhanced ultrasound) can better show if liver cancer treatment (radioembolization) killed the tumor, compared to standard CT or MRI scans. About 30 adults with liver cancer will get an ultrasound within two weeks of their…