GRAFT VS HOST DISEASE

This early-stage study is testing whether adding one or two drugs to standard transplant care can better prevent two serious complications: graft-versus-host disease (where donor cells attack the patient's body) and cytokine release syndrome (a severe immune reaction). The trial …

This study is testing an oral drug called pacritinib for adults with moderate to severe chronic graft-versus-host disease (cGVHD) that has not improved after at least two prior treatments. cGVHD is a serious immune reaction that can occur after a stem cell transplant. The goal is…

This early-stage study is testing a new type of stem cell transplant for people with aggressive or hard-to-treat forms of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). The goal is to see if adding special immune cells from a partially matched donor can help the…

This study is testing whether the drug ruxolitinib can help control chronic graft-versus-host disease in Chinese patients aged 12 and older when standard steroid treatments have failed. About 50 participants who have had a stem cell transplant will receive ruxolitinib and be foll…

This study is testing whether adding a drug called belumosudil to standard treatments can better prevent graft-versus-host disease (GVHD) in blood cancer patients who receive stem cell transplants. Researchers want to see if this approach helps patients live longer without GVHD o…

This study is for patients who develop a severe, life-threatening immune reaction (GVHD) after a stem cell transplant that doesn't respond to standard steroid treatment. It will test if adding a drug called etanercept to the current standard drug, ruxolitinib, works better than r…

This study is testing whether giving a drug called abatacept for a longer period of time is better at preventing severe complications after a stem cell transplant. It will involve about 160 patients, aged 2 and up, who have a blood cancer and are receiving a transplant from a par…

This study is testing if a home-based exercise program can help patients who develop Graft-Versus-Host Disease (GVHD) after a stem cell transplant. The goal is to see if exercise can improve blood sugar control, body composition, fitness, and quality of life while patients are on…

This study follows patients for years after they received a donor stem cell transplant to understand the long-term health effects. Researchers monitor for disease return, transplant complications, and late side effects from the original treatment. Participants undergo regular che…

This study aims to understand a painful complication called vulvovaginal graft-versus-host disease (GVHD) that can occur after a stem cell transplant. Researchers will observe 40 women to see if the community of bacteria in the vagina changes after the transplant and if those cha…

This study aims to create and test a new questionnaire specifically for children and teens living with chronic graft-versus-host disease (cGVHD), a serious and often painful side effect of stem cell transplants. Researchers will work with 420 children (ages 5-17) and their parent…

This study aims to understand why some people experience severe fatigue and thinking problems after stem cell transplants. Researchers will examine 30 transplant survivors to see if brain inflammation might be causing these symptoms. They'll use brain scans and spinal fluid tests…