GASTROPARESIS

This study tests a procedure called per-oral pyloromyotomy (POP) to see if it improves stomach emptying and reduces symptoms like nausea and vomiting in people with gastroparesis (slow stomach emptying) that hasn't gotten better with medication. About 100 adults aged 18-75 will b…

This program allowed patients aged 12 and older with severe stomach or gut problems like gastroparesis or GERD to try domperidone when standard treatments failed. The goal was to ease symptoms such as nausea, vomiting, and heartburn. The program is no longer available.

This pilot study from Mayo Clinic is testing whether virtual reality therapy is safe and tolerable for people with gastroparesis (stomach paralysis). The study aims to enroll 30 adults aged 18-75 with documented gastroparesis. Participants will use VR and report any side effects,…

This study tests two procedures—G-POEM (a tube through the mouth to relax the stomach muscle) and a stomach pacemaker (GES)—alone or together in 40 adults with severe gastroparesis (stomach paralysis) that hasn't improved with medication. The goal is to see which approach best re…

This study looks at how a stomach pacemaker (gastric electrical stimulation) affects the vagus nerve and heart rate in 300 adults with gastroparesis. Researchers measure heart signals and hormone levels when the device is on and off. The goal is to understand the body's response,…

This study tests a new device called Gastric Alimetry that maps the stomach's electrical activity using a sticker-like patch. Researchers will compare readings from 200 healthy adults and people with stomach motility problems to establish normal ranges and see how signals relate …

This study aimed to see if two tests (EndoFLIP and ADM) could predict which patients with severe, hard-to-treat gastroparesis would get better after a surgery called G-POEM. The study was withdrawn before enrolling any participants, so no results are available. It was designed fo…

This study explores whether stimulating a nerve in the outer ear can reach the vagus nerve, which controls stomach function. Researchers will measure nerve signals, heart rate, stomach electrical activity, and hormone changes in 131 healthy volunteers and people with gastroparesi…

This study looks at how the vagus nerve sends signals in people with gastroparesis who already have a gastric electrical stimulator device. Researchers will place a flexible, non-invasive electrode patch on the neck to measure nerve activity and see how it relates to symptom cont…