GASTROESOPHAGEAL CANCER

This early-phase study tests a new drug, BG-68501, in people with advanced solid tumors (like breast, ovarian, lung, or stomach cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors when used alone or with other…

This study tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers (like breast, stomach, lung, or ovarian cancer) that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and how long that effect last…

This early-phase trial tests a new drug called MDX2001 in about 285 adults with advanced solid tumors (cancers that have spread). The main goals are to check the drug's safety and find the right dose. Researchers will also see if it shrinks tumors. This is not a cure, but it may …

This early-stage trial tests a new drug called DA 3501 in adults with advanced stomach or pancreatic cancer that has a specific marker (CLDN18.2). The main goals are to find the safest dose and see if the drug can shrink tumors. Participants receive the drug every three weeks and…

This study tests a new combination of drugs—neratinib, trastuzumab, pembrolizumab, and chemotherapy—in people with HER2-positive stomach or esophageal cancer. The goal is to see how well the treatment shrinks tumors and controls the disease. About 36 adults will take part, and th…

This study is for people with stomach cancer that has spread to a few other places in the body. It tests whether adding surgery to remove the main tumor and some of the spread, along with other local treatments, to a mix of immunotherapy and chemotherapy helps people live longer …

This study tests a program called STRONG that uses remote check-ins and nutrition guidance to help people with gastroesophageal cancer avoid malnutrition during treatment. About 80 adults starting chemotherapy or radiation will be enrolled. The goal is to see if this approach is …

This study compares symptoms in patients who have one of two types of minimally invasive stomach cancer surgery: removing only the upper part of the stomach or the entire stomach. Researchers want to see which surgery leads to better appetite and fewer side effects. The study inv…

This study looks at whether a program of exercise and better nutrition can help people with incurable stomach or esophageal cancer feel better and maintain their quality of life. About 196 participants will either receive standard care or standard care plus a supervised exercise …

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer. Researchers will use these samples to develop and improve tests that detect cancer DNA in the blood, which may help monitor for cancer return or how well treatment is working. …