GASTROESOPHAGEAL CANCER

This study aimed to see if immune checkpoint drugs (nivolumab with or without ipilimumab) could help people with colorectal or gastroesophageal cancer delay or avoid major surgery. It planned to enroll adults with early-stage cancers. However, the study was withdrawn before any p…

This study tests a new treatment approach for people with advanced stomach or gastroesophageal junction cancer that has spread. Participants first receive targeted radiation and a drug called olaparib, followed by a combination of olaparib and pembrolizumab. The goal is to see if…

This early-phase trial tests whether giving immunotherapy drugs (nivolumab or nivolumab/relatlimab) before standard chemoradiation is safe and feasible for people with operable stage II/III esophageal or gastroesophageal junction cancer. The goal is to see if this approach can ch…

This study tests a new drug called MK-2870 against the doctor's choice of standard treatments for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has spread or cannot be removed. About 450 participants who have already tried at least two prior t…

This early-stage trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in 120 adults with advanced or metastatic solid tumors that have not responded to standard treatments. The main goal is to find safe doses and check for side effects, while also measur…

This study tests whether adding targeted radiation to the immunotherapy drug nivolumab (alone or with another drug, relatlimab) can help control advanced stomach, esophageal, or gastroesophageal junction cancer. About 21 adults with limited metastatic disease will receive radiati…

This study tests a remote nutrition program for people with gastroesophageal cancer who are getting chemotherapy and radiation. The program uses a mobile app and dietitian visits to support nutrition. The goal is to see if the program is practical and satisfying for patients. Abo…

This study tests a program that lets cancer patients receive care at home while undergoing chemotherapy or radiation. The goal is to see if remote monitoring and home support can reduce emergency room visits and hospital stays. About 300 adults with certain cancers (like pancreat…

This study looks for early signs of heart injury in people receiving radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to detect changes during or shortly after treatment. The goal is to identify patients at risk for heart problems and i…

This study aimed to look at genetic changes in gastroesophageal cancer that might help explain why some patients do not respond to immunotherapy. It was an observational study, meaning no treatment or drugs were given. Participants would have provided blood and tumor samples befo…