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Immunotherapy combo before Chemo-Radiation shows promise for esophageal cancer

NCT ID NCT03044613

First seen Apr 09, 2026 · Last updated Apr 30, 2026 · Updated 4 times

Summary

This early-phase trial tests whether giving immunotherapy drugs (nivolumab or nivolumab/relatlimab) before standard chemoradiation is safe and feasible for people with operable stage II/III esophageal or gastroesophageal junction cancer. The study involves 32 participants and aims to see if this approach changes the tumor environment to improve survival. The main focus is on safety and whether patients can proceed to surgery without major delays.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Alleghany Health Network

    Pittsburgh, Pennsylvania, 15212, United States

  • Baylor University/ Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

Conditions

Explore the condition pages connected to this study.