FOLLICULAR LYMPHOMA

This early-phase trial tested a new drug called BR101801 in 26 adults with advanced blood cancers like lymphoma and leukemia that had not responded to other treatments. The main goals were to find a safe dose and check for side effects. The study was completed, but results are no…

This study tested a new drug called BGB-10188, alone or combined with other cancer drugs, in 97 people with certain blood cancers (like lymphoma and leukemia) or advanced solid tumors. The main goals were to find safe doses and check for side effects. The trial was completed, but…

This study tested a new treatment called axicabtagene ciloleucel (a CAR T-cell therapy) in 159 adults with follicular or marginal zone lymphoma that had come back or stopped responding to at least two prior treatments. The therapy works by reprogramming a patient's own immune cel…

This study tested whether adding the drug ibrutinib to standard rituximab therapy helps people with untreated follicular lymphoma live longer without their cancer getting worse. About 445 patients aged 60 or older (or 60-69 with other health issues) took part. The goal was to see…

This study tested a new radiation schedule (once a week for 5 weeks) in 10 people with B-cell lymphoma that had come back or not responded to treatment. The goal was to see if this approach is practical and has fewer side effects before patients receive CAR T-cell therapy. The st…

This study tested a personalized cell therapy called tisagenlecleucel (a CAR-T treatment) in 98 adults with follicular lymphoma that returned or didn't respond to prior therapies. The treatment involves collecting a patient's own immune cells, reprogramming them to attack cancer,…

This study tested whether a combination of two drugs, rituximab and lenalidomide, works better than the usual rituximab plus chemotherapy for people with untreated follicular lymphoma. About 1,000 patients took part. The goal was to see if the new combo could better control the d…

This study tested a new treatment for children and young adults (ages 1-39) with B-cell leukemia or lymphoma that did not respond to standard therapy. Researchers took participants' white blood cells, modified them in a lab to target the CD22 protein on cancer cells, and infused …

This study tested a two-step stem cell transplant for people with high-risk blood cancers like leukemia and lymphoma. First, patients got low-dose chemotherapy and radiation to prepare the body. Then, they received donor immune cells followed by donor stem cells to help destroy c…

This study looked back at 30 people with HIV who were treated with CAR T-cell therapy for certain blood cancers like lymphoma or leukemia. Researchers collected standard medical data to see how often side effects occurred and how the immune system changed over time. The goal was …