FIBROSIS

This study tests whether two different drug combinations—pentoxifylline with vitamin E, or pravastatin alone—can prevent or reduce lymphedema (swelling) and fibrosis (scarring) caused by radiation therapy for head and neck cancer. About 295 adults who are about to receive radiati…

This study tests if adding medication can treat or prevent lymphedema and fibrosis—painful swelling and scarring—caused by radiation therapy in head and neck cancer survivors. About 250 participants who have finished radiation at least 6 months ago will receive one of several dru…

This study looks at whether giving copper supplements to people with cirrhosis (scarring of the liver) who have low copper levels can improve liver function and overall health. About 30 adults with cirrhosis and low or borderline copper will take copper or a placebo for a set tim…

This study tests a new inhaled drug, mosliciguat, added to an existing treatment (treprostinil) for people with high blood pressure in the lungs caused by scarring lung disease. About 20 adults will take part to see if the combination is safe and tolerable. The goal is to manage …

This study tests whether a special spa therapy can improve skin-related quality of life in people who have skin hardening (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly assigned to get spa …

This study looks at how well the diaphragm works in 800 people with lung diseases like asthma, COPD, fibrosis, or pulmonary hypertension. Researchers want to understand if diaphragm problems are linked to shortness of breath. No new treatments are being tested—this is an observat…

This study aims to find out if two types of HIV medications (NNRTI and INSTI) cause different levels of fatty liver disease in people with HIV. Researchers will screen 200 HIV patients using ultrasound to measure liver fat and stiffness. The goal is to learn which drug class may …