ESOPHAGEAL NEOPLASMS

This study tests whether adding omega-3 fatty acids (EPA and DHA) to standard immunotherapy (PD-1 inhibitors) can improve muscle mass and overall outcomes in adults with advanced esophageal cancer. About 142 participants will receive either omega-3 or a placebo for 6 months along…

This trial tests a new drug called UCB4594, an antibody that targets a protein (HLA-G) found on many cancer cells. The goal is to see if it helps the immune system attack tumors. It is for people with advanced solid tumors (like lung, breast, or colon cancer) that have not respon…

This study compares two surgeries—proximal gastrectomy and total gastrectomy—for people with locally advanced gastroesophageal junction cancer. About 120 adults aged 18 to 90 will be randomly assigned to one surgery type. The goal is to see which approach leads to better 3-year c…

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus standard chemotherapy, o…

This study tests whether adding new investigational drugs to standard chemotherapy and immunotherapy (pembrolizumab) can safely shrink tumors in people with advanced stomach, gastroesophageal junction, or esophageal cancer that has not been treated before. About 160 adults whose …

This early-stage study tests a new drug called LY4337713 in people with advanced cancers (like pancreatic, breast, ovarian, or colorectal) that have high levels of a protein called FAP. The drug delivers radiation directly to cancer cells. The main goals are to check safety, find…

This study is testing a structured rehabilitation program for 100 people in southern Sweden who have esophageal or stomach cancer and are scheduled for surgery. The goal is to see if the program can improve quality of life and reduce cancer-related symptoms. Participants will be …

This study tests a 6-week program combining bright light exposure with specific exercises to improve sleep, mood, and quality of life in people with lung or esophageal cancer. Researchers will track 200 participants' sleep patterns, symptoms, and survival rates for one year. The …

This study reviews past medical records of 2,000 adults who had an endoscopic procedure to remove cancerous or precancerous growths in the esophagus, stomach, duodenum, colon, or rectum. The goal is to compare different removal techniques and see how well they work and how safe t…

This study is collecting survey responses from 1,000 people who have had or will have surgery for esophageal cancer or other upper digestive problems. The goal is to create a standard way to measure symptoms and recovery after treatment. The information will help doctors better m…