END STAGE LIVER DISEASE

This trial tests whether a machine called Normothermic Machine Perfusion (NMP) can revive moderately fatty donor livers so they can be safely transplanted. Researchers will place livers with 30-60% fat on the machine, check their quality, and transplant those that meet safety cri…

This early-stage study tests whether a donor stem cell infusion, combined with low-dose radiation and immune-suppressing drugs, can retrain the immune system to accept a liver transplant without long-term anti-rejection medication. Up to 12 adults who have had a living-donor live…

This study tests if a drug called darbepoetin can lower the need for blood transfusions during liver transplant surgery. About 140 adults on the liver transplant waiting list with low hemoglobin will receive either the drug or a placebo. The goal is to see if the drug safely redu…

This study tests whether eating protein evenly throughout the day combined with exercise can improve nutrition, muscle mass, and physical function in 90 adults awaiting a liver transplant. Participants are split into three groups: even protein plus exercise, uneven protein plus e…

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This study tests a home monitoring program called LiverWatch for people with advanced liver disease (cirrhosis). Participants get a Fitbit, personalized nutrition advice, and weekly check-ins to boost activity and manage symptoms. The goal is to see if this approach improves phys…

This study tests if drinking a carbohydrate beverage before liver transplant surgery helps patients recover more quickly and spend fewer days in the hospital. About 434 adults receiving a liver transplant will be randomly assigned to drink either the carbohydrate drink or a place…

This study follows 275 infants who received a liver transplant to see how they grow and develop over time. Researchers want to find patterns that can help doctors improve care and follow-up plans. The study is only observing children, not testing a new treatment.

This study looks at whether measuring a substance called FMN in the fluid used to preserve donated livers can predict how well the liver will work after transplant. Researchers will collect samples from 850 liver transplant patients at multiple hospitals. The goal is to see if FM…

This study looks at how frailty, nutrition, muscle loss, and mental health affect people waiting for a liver transplant. Researchers will measure physical strength, walking ability, and daily function, along with diet and emotional well-being. The goal is to see which factors pre…

This study tests a web-based app that helps people waiting for a kidney or liver transplant share their story on social media to find a living donor. Researchers want to see if this approach brings in more potential donors and leads to more transplants. The study involves 1000 ad…

This study from Mayo Clinic aims to understand the individual and social reasons why some patients with end-stage liver disease are not listed for or do not receive a liver transplant. Researchers will track 100 patients to see who gets on the waiting list, who receives a transpl…