Machine breathes new life into fatty livers for transplant
NCT ID NCT06088758
First seen Nov 03, 2025 · Last updated Jun 23, 2026 · Updated 39 times
Summary
This trial tests whether a machine called Normothermic Machine Perfusion (NMP) can revive moderately fatty donor livers so they can be safely transplanted. Researchers will place livers with 30-60% fat on the machine, check their quality, and transplant those that meet safety criteria. The goal is to increase the number of usable donor livers and reduce waitlist deaths.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Massachusetts General Brigham
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Normothermic machine perfusion (NMP) device
What this could lead to
If successful, this could allow more fatty livers to be used for transplant, reducing waitlist deaths and expanding the donor organ pool.
What could go wrong
This is an early-stage, single-site trial with only 200 participants. The procedure may not work for all fatty livers, and there are risks of poor graft function or need for retransplant.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.