EARLY STAGE BREAST CANCER

This study tests whether giving a short course of radiation to the tumor area before surgery is safe and practical for women with early-stage breast cancer. About 98 women over age 50 with small, low-grade tumors will receive radiation, then have surgery. The main goal is to chec…

This study tests whether a 1-week course of radiation after breast-conserving surgery works as well as the standard 3-week course for early-stage breast cancer. About 72 adults with ductal carcinoma in situ or early invasive breast cancer will be enrolled. The goal is to see if t…

This study looks at a type of radiation therapy for early-stage breast cancer where tiny radioactive seeds are placed directly into the breast after a lumpectomy. The goal is to improve the technique and see how well patients tolerate it, as well as compare costs with other radia…

This study looks at 100 women with early-stage HR+/HER2- breast cancer to see if adding CDK4/6 inhibitors to standard hormone therapy before surgery improves outcomes. Researchers use a genetic risk score and early changes in a cell growth marker (Ki-67) to decide who gets the ex…

This study tests whether adding the targeted drug pyrotinib to standard chemotherapy can better shrink tumors before surgery in people with a specific type of early breast cancer (HR-positive, HER2-low, high-risk). About 160 participants will receive either the drug combo or chem…

This study tests whether starting abemaciclib at a lower dose and gradually increasing it causes fewer side effects than the standard fixed dose. About 90 adults with early-stage, hormone receptor-positive breast cancer will take part. The goal is to see if this approach helps pe…

This study tests a portable cooling cap worn during chemotherapy to prevent hair loss in women with early-stage breast cancer. The cap cools the scalp to reduce damage to hair follicles from chemo drugs. The study involves 40 women and measures how well the cap works and any side…

This study follows 450 premenopausal women with early-stage hormone-positive breast cancer to see how their quality of life changes during treatment with triptorelin and other hormone therapies. Researchers will also track treatment effectiveness, safety, and how well patients fo…

This study follows 94 women aged 50 and older with early-stage, low-risk breast cancer who received a single dose of radiation during surgery (IORT). Researchers track cancer recurrence, side effects, and quality of life over time. The goal is to gather real-world data on how wel…