Dry eye disease

This trial tests whether an experimental eye drop made of tiny fat bubbles, called liposomes, can improve the health of the eye surface and tear film in adults with dry eye disease. Participants will use one drop in each eye three times a day for four weeks. Researchers will meas…

This trial tests whether cyclosporine eye drops, a treatment for dry eye disease, can help maintain the health of corneal endothelial cells—the cells that keep the cornea clear. About 204 adults with dry eye will receive either cyclosporine drops or a saline solution for 12 month…

This study tested whether a new eye drop called AR-15512 can improve the health of the eye surface in people with dry eye disease. 80 participants received either the new drops or artificial tears. The main goal was to see if the drops increased the number of goblet cells, which …

Researchers are testing whether a new eye gel called Myrialen works as well as an existing gel called Recugel in people with moderate to severe dry eye syndrome. Both gels contain 5% dexpanthenol and are applied as drops four times a day for 30 days. The trial enrolls about 125 a…

This early-stage trial tested an experimental eyedrop called INV-102 in 84 adults with moderate dry eye disease. The study had two parts: first, checking safety at different doses, and second, seeing if the drops improve eye dryness symptoms after two weeks. Participants used the…

Researchers are testing an experimental eyedrop called INV-102 in adults with moderate to severe dry eye disease. The trial compares INV-102 with a vehicle drop over four weeks of repeated dosing. The main goal is to see whether INV-102 reduces corneal damage, measured by a stand…

This study tests a new artificial tear called ABBV-444 against an existing brand, Refresh Optive, in 250 adults with dry eye disease. Participants use the assigned eye drops for 90 days. The goal is to see if the new formula improves eye comfort and surface health better than the…

Researchers are testing tivanisiran sodium eye drops in adults with dry eye disease to see if the drops are safe when used once daily for a year. About 300 participants will receive either the tivanisiran drops or a vehicle drop, which is a solution without the active ingredient.…

This study compares two lubricating eye drops—Systane PRO PF and Thealoz Duo—to see which one better relieves dry eye symptoms. About 100 adults with dry eye will use each drop for 4 weeks, one twice a day and the other four times a day. The goal is to find out if they work equal…

This study is testing two new artificial tear formulas to see if they are safe and well-tolerated in people with moderate dry eye disease. Researchers will monitor for side effects and eye health in 148 participants who already use artificial tears. The goal is to find better opt…

This Phase 2 trial tests a new eye drop that combines two active ingredients—lifitegrast and perfluorohexyloctane—for people with dry eye disease. About 423 adults will use the drops twice daily for 4 weeks. Researchers will measure changes in eye surface staining and symptom sco…

This study tests an experimental eye drop called GRF312 5% in 100 adults with dry eye disease. The goal is to see if it is safe and helps relieve symptoms. Participants will use the drops at home and attend clinic visits for check-ups.

This study tested whether using the Systane iLux device—which applies heat and pressure to the eyelids—before cataract surgery could improve dry eye symptoms. Thirty adults scheduled for cataract surgery received the treatment in one eye. Researchers measured changes in tear film…

This study tested whether a nasal spray containing varenicline (OC-01) can improve tear film quality and reduce dryness in people with dry eye disease. Fifty adults used either the active spray or a placebo. Researchers measured tear film changes and symptom scores shortly after …

This study tested three ways to use an eyelid wipe soaked with IVW-1001, a dry eye treatment, in 30 people with dry eye disease. Researchers measured changes in tear production and checked for any vision changes. The goal was to find the best wiping technique for safety and sympt…

This study tested the safety of AR-15512 eye drops in 55 people with dry eye disease. Participants received the drops at different temperatures and with eyes open or closed to see if these factors affect side effects. The goal was to measure how many people had eye-related side e…

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested a new eye drop formula in 188 adults with mild to moderate dry eye disease. Participants used the drops for 30 days and reported how much their symptoms bothered them. The goal was to see if the drops safely improve comfort.

This phase 2 trial tested two strengths of rhNGF eye drops against a placebo in 317 adults with moderate-to-severe dry eye disease. Participants used the drops three times a day for 4 weeks, followed by 4 weeks of monitoring. The goal was to see if the drops could improve dry eye…

This study tested a new medicated eyelid wipe called IVW-1001 in 150 adults with dry eye disease. Participants used either a low dose, a higher dose, or a placebo wipe. The goal was to see if the wipe is safe and can improve tear production and eye comfort.

This completed Phase 3b trial tested AR-15512 eye drops in 81 adults with dry eye disease. The goal was to see if a single dose could quickly increase tear production, measured by tear meniscus height. The study was open-label, meaning everyone knew they were getting the active d…

This Phase 3 trial tested SI-614 eye drops, a modified form of sodium hyaluronate, against placebo in 232 adults with dry eye disease. Participants used the drops four times daily for 84 days. The study measured changes in eye surface staining (a sign of damage) and daily symptom…

This completed Phase 3 trial tested whether 0.25% reproxalap eye drops can reduce discomfort from dry eye disease better than a placebo. 116 adults with dry eye for at least 6 months used the drops six times over two days. The main goal was to measure changes in eye discomfort us…

This study tested the safety of reproxalap eye drops in 757 adults with dry eye disease. Participants used the drops for up to one year. The main goal was to check for serious side effects like vision changes or eye pressure increases. Results will show whether the drops are safe…

This Phase 3 study tested cenegermin (Oxervate) eye drops against a placebo in 85 adults with severe dry eye caused by Sjogren's syndrome, who were already using cyclosporine drops. The goal was to see if cenegermin could increase tear production and reduce eye discomfort over 4 …

This Phase 2 trial tested an experimental eye drop called SHJ002 in 85 adults with dry eye disease. The drops are designed to block a specific microRNA linked to inflammation. Researchers measured changes in corneal staining and symptom scores over 84 days to see if the drops are…

This Phase 3 trial tested whether reproxalap eye drops can safely reduce discomfort in people with dry eye disease. 421 adults used the drops or a placebo for up to 6 weeks. The main goal was to measure changes in eye discomfort scores over time.

This study tested whether auricular acupuncture (tiny needles on the ear) can relieve dry eye symptoms in university students. Fifty students with dry eyes received either real ear acupuncture or a sham version, plus artificial tears, for four weeks. Researchers measured symptom …

This study tracks 378 people with moderate to severe dry eye disease and healthy volunteers to see how signs, symptoms, and biomarkers change after treatment with either Vevye or Xiidra eye drops. The goal is to find better ways to measure the disease and its response to therapy.…