DIABETIC FOOT

This study tests whether a special graft made from donated placental tissue can help heal diabetic foot ulcers that won't close with standard care. About 60 adults with type 1 or 2 diabetes will receive either the graft plus usual wound care or usual care alone. The main goal is …

This study tests whether adding a special placental-based skin graft to usual wound care helps close hard-to-heal diabetic foot ulcers faster than usual care alone. About 272 adults with diabetes and foot sores that haven't healed after 4 to 52 weeks will take part. The main goal…

This study tests a new procedure that reroutes blood flow in the foot to save the leg from amputation. It is for people with severe leg artery disease who have no other treatment options. The study will check if the procedure is safe and works well in 50 participants.

This study looks at whether opening blocked leg arteries within 48 hours (early angioplasty) helps heal foot ulcers faster in people with type 2 diabetes compared to waiting for a scheduled procedure. Researchers will track wound healing with a 3D camera and study how the wound's…

This study tests a smart mat that checks foot temperature at home to prevent diabetic foot ulcers. It involves 800 Veterans with diabetes who have had a foot ulcer or amputation. The mat sends data to a monitoring team that alerts VA providers if a problem is detected, aiming to …

This study tests whether special smart insoles can help prevent foot ulcers from coming back in people with diabetes and nerve damage. The insoles measure pressure and temperature on the feet and alert the user to problem areas. 400 high-risk participants will be followed to see …

This study tests if a cream made with a special form of capsaicin (the stuff that makes chili peppers hot) can reduce foot pain in people with diabetic nerve damage. About 80 adults with diabetic foot pain will apply the cream or a placebo twice a day for 14 days and rate their p…

This study aims to find biological markers (biomarkers) that can predict whether a diabetic foot ulcer will heal or not. Researchers will collect samples like blood and wound fluid from 5,000 adults with diabetes and an open foot ulcer. The goal is to develop tools that help doct…

This study looks at how biofilm infections in diabetic foot ulcers affect the skin's barrier function after the wound closes. Researchers will measure water loss through the healed skin to see if it's linked to the wound coming back. The goal is to understand the role of biofilm …

This study looks at how immune cells affect healing in people with diabetes and chronic foot ulcers. Researchers will compare blood and tissue samples from 40 patients whose ulcers are healing versus those that are not. The goal is to find differences in immune cell activity that…