CRC

This study tests whether adding a combination of two antibiotics and aspirin to standard chemotherapy can help people with stage IV colorectal cancer. About 97 participants will receive either chemo alone or chemo plus the microbiome therapy. The goal is to see if the added treat…

This study is testing several new experimental drugs called RAS(ON) inhibitors, alone or with standard chemotherapy, in people with advanced colorectal or pancreatic cancer that has spread. About 1,130 adults will participate to see if these combinations are safe and can shrink t…

This study tests a new drug called RMC-5127 in people with advanced solid tumors that have a specific KRAS G12V gene change. The drug is given alone or with other medicines to see if it is safe and can shrink tumors. About 574 adults who have already tried other treatments will t…

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 80 participants will receive the drug through an IV, and r…

This study tests a combination of experimental drugs (RAS(ON) inhibitors plus ivonescimab) in adults with advanced solid tumors that have a RAS mutation. The goal is to see if the combination is safe and can shrink or control tumors. About 370 participants whose cancer has worsen…

This study tests a new drug called HCB101 combined with standard treatments (cetuximab or bevacizumab plus chemotherapy) in people with advanced or metastatic colorectal cancer. The goal is to find a safe dose and see if the combination shrinks tumors. About 40 adults will partic…

This study tests a new type of CAR T cell therapy for adults with advanced solid tumors, including colorectal, pancreatic, lung, ovarian, and mesothelioma cancers. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells that have lost a specif…

This study tests a new drug combination (HS-20110) in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find the safest dose and see if it can shrink tumors. About 500 adults will take part in this early-phase trial across multip…

This early-phase trial tests a new drug, TUB-030, in adults with advanced solid tumors like head and neck, lung, breast, or colorectal cancer. The main goals are to find a safe dose and check for side effects. Researchers will also compare different doses in people with head and …

This study tests a new treatment called A2B395 for adults with advanced solid tumors (like colorectal, lung, breast, and kidney cancers) that have not responded to standard therapy. The treatment uses specially engineered immune cells designed to kill cancer cells while protectin…

This study is gathering tumor tissue and blood cells from 200 adults with advanced solid tumors like colorectal, lung, or pancreatic cancer. The goal is to learn how often certain genetic changes occur and to store participants' own immune cells for possible future use in making …