CRC

This study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have returned or spread. The therapy, called Tmod CAR T cells, is designed to find and kill cancer cells while trying to avoid harming the patient's healthy cells. Researchers…

This early-stage study is testing a new drug called RMC-5127, both by itself and combined with other cancer drugs, in adults with advanced solid tumors that have a specific genetic change called KRAS G12V. The main goals are to find safe doses and see how the body processes the d…

This study is testing a new drug, TUB-030, to see if it is safe and can help control advanced solid cancers in adults. Researchers will give the drug every three weeks to find the highest dose patients can tolerate. They will also look for early signs that the drug might work, es…

This early-stage trial is testing whether adding an experimental drug called HCB101 to standard chemotherapy treatments can help control advanced colorectal cancer that has spread. The study will enroll 40 adults whose cancer has worsened despite previous treatment, focusing firs…

This study is testing whether adding a combination of two common antibiotics (ciprofloxacin and metronidazole) and aspirin to standard chemotherapy helps people with advanced colorectal cancer. Researchers want to see if changing the bacteria in the gut (the microbiome) can make …

This study is testing new combinations of experimental drugs for people with advanced solid tumors that have specific RAS mutations. Researchers want to see if combining a new type of drug called a RAS(ON) inhibitor with another cancer drug called ivonescimab is safe and can help…

This is the first study in people to test a new drug called CBI-1214, which is designed to help the body's own immune cells attack cancer. It is for adults with advanced or metastatic colorectal cancer that has continued to grow despite prior standard treatments. The main goals a…

This study is testing new targeted drugs called RAS inhibitors in combination with standard cancer treatments for people with advanced colorectal or pancreatic cancer. The goal is to find safe and effective doses while seeing if these new drug combinations can help control cancer…

This study is testing a new type of cell therapy called A2B395 for adults with advanced solid tumors that have spread or returned. The therapy uses modified immune cells designed to specifically kill cancer cells while protecting the patient's healthy cells. The main goals are to…

This study is preparing for future cancer treatment trials by collecting information and materials from patients. Researchers will analyze tumor tissue from people with advanced solid tumors and collect their white blood cells through a procedure called apheresis. The collected c…