COLORECTAL ADENOMA

This study tests whether linaclotide, a drug that helps the intestines release water and salt, can slow or prevent colorectal cancer. About 230 people with colorectal adenomas (precancerous growths) or early-stage colorectal cancer will take the drug or a placebo before surgery. …

This study checks how well a new stool test called LifeKit® finds colorectal cancer and precancerous polyps. About 12,000 adults aged 40 and older who are already scheduled for a screening colonoscopy will provide a stool sample. The goal is to see if the test is accurate enough …

This study tests a computer program that analyzes colonoscopy images to help doctors decide if a growth (polyp) is likely cancerous (adenoma) or not. About 1,178 adults with confirmed polyps will have their images reviewed by the software. The goal is to see if the AI can accurat…

This study looks at whether taking aspirin in a specific pattern can help prevent colorectal cancer in people who already have growths called adenomas. Aspirin may block certain enzymes that help cancer cells grow. The trial involves 81 adults with colorectal adenomas and measure…

This study tests a vaccine that helps the immune system recognize and attack cells in advanced colon polyps, which can turn into cancer. About 110 people who recently had such polyps removed will receive either the vaccine or a placebo. The goal is to see if the vaccine boosts im…

This study looks at tissue samples from 582 people with colon cancer, colon polyps, or healthy colons to compare cancer-related markers and gut bacteria. The goal is to better understand how colon cancer develops, not to test a new treatment. Results may help future detection or …