COLONIC NEOPLASMS

This study looks at whether keyhole surgery (laparoscopic) or traditional open surgery leads to better long-term results for colon cancer patients who have extra belly fat. About 664 adults aged 18 to 75 with colon cancer and a high Body Roundness Index will take part. The main g…

This study tests whether the immunotherapy drug dostarlimab, given before and after surgery, works better than standard treatments for a specific type of colon cancer (dMMR/MSI-H, stage III or T4N0). About 892 participants will be randomly assigned to receive either dostarlimab o…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study aims to find out if stool or blood samples can spot colon cancer or precancerous polyps as early as a colonoscopy. Researchers will collect samples from 1,200 adults, including those with cancer, polyps, or at risk, to look for specific proteins (biomarkers). The goal …

This study tests ways to improve colorectal cancer screening in Appalachia by mailing fecal immunochemical test (FIT) kits to 500 people who are due for screening. Some participants get an enhanced kit with a video brochure and gloves, plus phone or text reminders. The goal is to…

This study looks at whether aerobic exercise can help people with stage II or III colon cancer tolerate more of their planned chemotherapy. About 219 participants who have had surgery and are about to start chemo will be randomly assigned to an exercise program or a control group…

This study looks back at medical records of 2000 adults who had endoscopic removal of cancerous or precancerous growths in the esophagus, stomach, duodenum, colon, or rectum. The goal is to compare different removal methods to see which works best and has the fewest complications…