COLONIC NEOPLASMS

This study tests whether the immunotherapy drug dostarlimab, given before and after surgery, works better than standard treatments for a specific type of colon cancer (dMMR/MSI-H, stage III or T4N0). About 892 participants will be randomly assigned to receive either dostarlimab o…

This study looks at whether keyhole (laparoscopic) surgery or traditional open surgery leads to better long-term outcomes for people with colon cancer who have extra belly fat. About 664 adults aged 18 to 75 with a specific body shape measure will take part. The main goal is to s…

This early-phase study tests a new treatment called TNhYP218 CAR T cells for people with solid tumors that have high levels of a protein called mesothelin, including mesothelioma. Participants' own immune cells are collected, modified in a lab to better attack cancer, and then gi…

This study aims to find out if stool or blood samples can spot colon cancer or precancerous polyps as early as a colonoscopy. Researchers will collect samples from 1,200 adults, including those with cancer, polyps, or at risk, to look for specific proteins (biomarkers). The goal …

This study looks at ways to improve colorectal cancer screening in Appalachia by mailing FIT kits and offering patient navigation. About 500 average-risk adults who are not up-to-date on screening will take part. The goal is to see which strategies help more people complete the t…

This study looks at whether adding aerobic exercise (like walking or cycling) during chemotherapy helps colon cancer patients receive a higher dose of their cancer treatment. Researchers will compare two groups: one that exercises and one that does not. The goal is to see if exer…

This study looks back at medical records of 2000 adults who had endoscopic removal of cancerous or precancerous growths in the esophagus, stomach, duodenum, colon, or rectum. The goal is to compare different removal methods to see which works best and has the fewest complications…