CHRONIC PANCREATITIS

This early-phase trial tests whether adding a patient's own bone marrow stem cells to an islet transplant can help preserve insulin production and reduce diabetes after pancreas removal for chronic pancreatitis. About 42 adults will be randomly assigned to receive stem cells or s…

This study tests an artificial intelligence system that analyzes contrast-enhanced CT scans to help doctors decide the best course of action for people with suspected pancreatic diseases. The AI will classify patients into three groups: needing immediate treatment, close monitori…

This study aims to see if a mixed meal test can better diagnose type 3c diabetes, which is caused by pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and either pancreatic cancer or chronic pancreatitis. The g…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice every day. Researchers will check if the juice reduces inflammation and improves symptoms and quality of life. About 35 adults will participate, and everyone will…

This early-stage study tests if stem cells taken from a patient's own bone marrow can reduce long-term pain caused by chronic pancreatitis. Researchers will also check if the treatment improves pancreas function and quality of life. The study involves 40 adults with confirmed chr…

This study tests if a single infusion of donor stem cells can reduce long-term pain in people with chronic pancreatitis. Researchers will track pain scores, opioid use, and quality of life in 48 adults over six months. The goal is to find a new way to manage pain that doesn't rel…

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. About 24 adults who have been on opioids for at least 4 weeks will take lacosamide for 7…

This study follows 35 adults with chronic pancreatitis who receive a nerve block (EUS-CPN) to manage their pain. Researchers will track pain levels and pain medication use weekly for 24 weeks after the procedure. The goal is to see if the nerve block helps reduce pain and the nee…

This study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain how the brain perceives pain. Adults with chronic pancreatitis and persistent abdominal pain not helped by standard treatments will receive 5-10 sessions and be fol…

This pilot study tests whether simvastatin, a common cholesterol medication, can improve quality of life in adults with recurrent acute or chronic pancreatitis. Researchers will enroll 90 participants to see if the treatment is feasible and acceptable. The goal is to reduce sympt…

This study tests an internet-delivered pain self-management program for adults with chronic pancreatitis. The goal is to reduce pain severity and its impact on daily activities, improving quality of life. Participants use a personal device or borrow one to access the program.

This early study tests whether a vitamin D-like drug called paricalcitol can improve quality of life for people with chronic pancreatitis. About 24 adults will take the drug or a placebo for 12 months. Researchers will check if the treatment is practical and acceptable, and measu…

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By applying mild stimuli, researchers hope to group patients by pain type and eventually predict who will benefit from specific treatme…

This study looks at the fluid made by the pancreas in healthy people. Researchers will collect this fluid during an endoscopy after giving a hormone called secretin. The goal is to learn what normal pancreatic fluid looks like, which can help doctors better understand and treat p…

This study collects blood, tissue, and health information from up to 20,000 people with pancreas diseases like pancreatic cancer or pancreatitis. Researchers will use these samples and data to better understand these conditions and develop better screening methods in the future. …

This study collects blood, saliva, urine, and stool samples from up to 1,600 children with recurrent or chronic pancreatitis. Researchers hope to find genetic markers that might predict a higher risk of developing pancreatic cancer later in life. The study does not offer a treatm…

This study uses a special blood test (MBT) to find people with chronic or recurrent pancreatitis who have mild-to-moderate trouble digesting fat. About 80 adults will take part. Some will then receive pancreatic enzyme pills or a placebo for 8 weeks to see if their quality of lif…

This study is a registry that will follow 510 adults who receive therapeutic endoscopic ultrasound (T-EUS) for conditions like blocked bile ducts, pancreatitis, or stomach blockages. Researchers will track how well these procedures work and any complications, comparing them to st…

This study is following 1,250 people who are at higher risk for pancreas cancer, such as those with new diabetes, pancreas cysts, or a family history. Researchers will collect blood samples and health information over time to find early warning signs of the disease. The goal is t…

This study looks at how well transplanted insulin-making cells (islets) work in people with chronic pancreatitis who have their pancreas removed. Researchers will collect blood samples to measure inflammation and graft function. The goal is to understand what affects long-term su…

This study aims to find ways to predict which people with chronic pancreatitis will get pain relief from a procedure called endoscopic therapy. Researchers will use brain tests, pain sensitivity tests, and questionnaires before the procedure. They will then follow 100 adults for …

This study creates a registry for people with pancreatic diseases or a high risk of pancreatic cancer, including those with family history or certain genetic mutations. Researchers collect health data and blood samples to study causes and find early detection markers. The goal is…

This study is testing a new method called Pancreatic Quantitative Sensory Testing (P-QST) to see if it can predict which patients with chronic pancreatitis will have less pain after a procedure like endoscopy or surgery. About 150 adults with chronic pancreatitis and blocked panc…