CHRONIC MIGRAINE

This study looks at how well the drug rimegepant works to prevent migraines in 100 people with episodic or chronic migraine. Participants will take rimegepant and report changes in their monthly migraine days over three to twelve months. The goal is to see if the drug reduces mig…

This study tests a device called PRIMUS that is implanted under the skin to stimulate nerves in the head and neck. It is for people with chronic or frequent migraine who have not gotten relief from at least three preventive medications. The goal is to see if the device safely red…

This study tests a daily pill called atogepant to prevent chronic migraines in teenagers aged 12 to 17. About 420 teens will receive either the drug or a placebo for 12 weeks. The goal is to see if the drug safely reduces the number of migraine days compared to a placebo.

This study follows 100 children under 18 who are already using a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life over …

This study tests if Xeomin injections can prevent chronic migraines in adults. About 780 people will get either Xeomin or a placebo injected into head and neck muscles. The main goal is to see if Xeomin reduces the number of migraine days per month over 6 months. Participants wil…

This study is checking the safety and effectiveness of atogepant, a drug already approved for migraine prevention, in Korean adults with chronic or episodic migraines. About 3000 people whose doctors prescribe atogepant will take the pill as usual and be followed for up to 12 wee…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) works better than CBT alone for preventing migraines in children aged 7-17. Researchers will track headache days and disability over time. The goal is to find the best first-…

This study tests an injection called IPN10200 to prevent migraines in adults with episodic or chronic migraine. The drug works by blocking pain-causing chemicals in the brain. About 641 participants will receive either the drug or a placebo to find the safest and most effective d…

This study is testing a drug called rimegepant to see how well it stops migraine pain and if it causes side effects. About 100 adults with migraines will take the pill during an attack and report their pain levels. The goal is to find a fast, effective treatment for migraine suff…

This study tests if a gentle, non-invasive brain stimulation (tDCS) given for 20 minutes each day for 20 days can reduce migraine pain. About 60 people with chronic migraine will get real or sham treatment, and 20 with episodic migraine will be observed only. The goal is to see i…

This study tests a short talk therapy called Well-Being Therapy (WBT) in 30 adults with chronic migraine. The goal is to see if WBT can reduce migraine-related disability, pain, and distress while boosting overall well-being. Participants will be randomly assigned to WBT or a con…

This study is testing a mind-body program delivered by nurses to help children and teens with migraine have fewer headache days. The program combines different treatment parts to find the best approach. About 260 kids with migraine will take part. The goal is to see if this progr…

This study tests if adding laser acupuncture to regular medication can help people with chronic migraine who don't get enough relief from drugs alone. About 60 adults will receive either real or fake laser acupuncture to see if it reduces migraine days and the need for painkiller…

This study tests a lifestyle behavior program to help people with chronic migraine reduce how often and how severely their headaches happen. Researchers will also look for biological markers linked to improvement. The goal is to see if the program is practical and liked by partic…

This study tests if Acceptance and Commitment Therapy (ACT), a type of talking therapy, can help adults with chronic migraine do more of their daily activities. About 40 people will either get ACT plus their usual care, or just usual care. Over a year, they'll answer questions an…

This study tests whether cannabis (CBD) can reduce the number of headache days in people with chronic migraines. About 72 adults will receive either a low or high dose of CBD or a placebo. Researchers will compare headache frequency before and after treatment to see if CBD helps …

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to see if daily changes in these factors can predict whether pain becomes long-term or flares up. A smaller group will also …