Cardiovascular risk factor

This study tests whether a Mediterranean diet with low-TMAO foods can lower levels of TMAO, a gut bacteria byproduct linked to heart disease. Researchers will compare this diet to standard heart-healthy advice in 170 adults with high TMAO. The goal is to see if diet alone can red…

This study tests whether adding the drug fostemsavir to standard HIV treatment can lower the risk of heart disease in people with well-controlled HIV. Researchers will compare heart imaging and blood tests between 150 adults who get the extra drug and those who don't. Participant…

Researchers test whether lowering systolic blood pressure to below 120 mm Hg prevents major cardiovascular events in adults with type 2 diabetes and high-normal blood pressure. The trial enrolls about 11,400 people aged 45 to 79. Participants receive either intensive treatment wi…

This study looks at whether offering coronary artery calcium (CAC) scans at no charge encourages more people to get screened for heart disease risk and leads to more preventive care, like statin prescriptions. The trial compares people who received a free CAC scan to those who pa…

This study tests whether regular, personalized health coaching—delivered virtually and during community screenings—can reduce the 10-year risk of heart attack or stroke in adults aged 40-75 who have at least one cardiometabolic risk factor like high blood pressure, high cholester…

This study is observing 3000 adults with various types of heart failure to learn how the disease develops and progresses. Researchers will collect medical records, blood samples, and imaging data to identify distinct patient groups. The goal is to match the right treatments to th…

This study explores how different sleep durations—short (6 hours or less), long (9 hours or more), and average (7-8 hours)—relate to cardiovascular health, physical activity, and sleep quality. Researchers will measure blood vessel function, blood pressure, and sleep patterns in …

This study is collecting medical information and blood/urine samples from 9,500 people with various heart and blood vessel conditions, plus healthy volunteers, over 20 years. The goal is to find better ways to diagnose heart disease and predict how patients will do in the future.…

This study looks at how dietary potassium affects blood vessel health in people who eat a lot of salt. Researchers will give 90 healthy adults different combinations of potassium and sodium diets for 10 days each. They will measure changes in artery function and blood pressure to…

This study looks at how blood pressure and artery stiffness change over 24 hours in people at increased risk for heart disease, especially those with kidney problems. Researchers will monitor 120 participants using a wearable device and collect blood and urine samples. The goal i…

This study is tracking 1,000 adults with psoriasis to see how their skin condition relates to heart disease. Researchers will use blood tests and heart imaging to find early signs of heart problems. The goal is to better understand why people with psoriasis have higher rates of h…