CARDIOMYOPATHY

This early-stage study tests whether donor bone marrow stem cells can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive standard heart failure care alone or with st…

This study looks at how well a drug called mavacamten works for adults in Japan who have a heart condition called obstructive hypertrophic cardiomyopathy (HOCM) and are already taking another drug, cibenzoline. The goal is to see if mavacamten helps improve blood flow from the he…

This study compares two common heart failure medications, carvedilol and metoprolol, in 2,000 adults who have an implantable cardioverter defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal…

This study tests artificial intelligence (AI) programs that help doctors interpret heart ultrasound images (echocardiograms). The goal is to see if the AI makes it easier and faster to diagnose specific heart conditions like genetic cardiomyopathy, blocked arteries, and cardiac a…

This study tests whether exercising in a community or home setting can improve exercise ability and quality of life for adults aged 18–85 with reduced heart or lung function. Two hundred participants will do 40–60 minutes of exercise five times a week for eight weeks, choosing ac…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with arrhythmias like atrial fibrillation or ventricular tachycardia. The goal is to see if it is safe and can create detailed maps to guide treatment. Sixty participants w…

This study is testing a new, detailed MRI scan to see if it can better detect and understand different types of heart disease. Researchers will scan 2000 adults with suspected or confirmed heart conditions and track their health over time. The goal is to create a standard imaging…

This study aims to find the genes that cause inherited heart and muscle diseases, such as cardiomyopathy, arrhythmia, and muscular dystrophy. Researchers will collect DNA samples from patients and their families to identify mutations linked to these conditions. The study is open …

This study watches how heart disease develops and changes over time in people with Friedreich ataxia, a rare genetic condition. Researchers will track heart measurements in 65 participants aged 6 and older to learn more about the disease. The goal is to better understand the cond…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…

This study aims to understand how different types of changes in the DMD gene are linked to heart problems in boys and young men with Duchenne or Becker muscular dystrophy. Researchers will use heart tests and blood samples to look for early signs of heart issues. The study involv…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers want to see if a genetic marker called TRPC6 can predict who will develop heart problems. By analyzing blood samples, they hope to find early warning signs and ways to p…

This study looks at whether certain genes make some people more likely to develop a weak heart muscle (cardiomyopathy) from atrial fibrillation (AF). Researchers will compare the DNA of 299 adults with AF who had heart recovery, those who didn't, and healthy controls. The goal is…

This study is for people with light chain amyloidosis, a rare disease where abnormal proteins build up in the heart and other organs. Researchers will use special PET and MRI scans to take detailed pictures of these protein deposits in the heart. The goal is to better understand …

This study checks if two different versions of HRS-1893 tablets are absorbed the same way in the body. It involves 36 healthy adults aged 18 to 55. The main goal is to measure drug levels in the blood and watch for any side effects. This is an early-stage study, so it does not of…