CARCINOMA, NON-SMALL -CELL LUNG

This study tested a new way to plan radiation therapy for non-small cell lung cancer. Researchers used a special MRI scan with inhaled xenon gas to create a detailed 3D map of how well a patient's lungs are working. The goal was to use these maps to guide radiation beams away fro…

This early-stage study tested a new oral drug called TRX-221 for people with advanced lung cancer driven by an EGFR gene mutation, whose disease worsened after standard treatments. The main goals were to find a safe dose and see if the drug could shrink tumors. The trial was term…

This study aimed to see if a daily pill called pralsetinib works better than standard chemotherapy as the first treatment for people with advanced lung cancer that has spread and has a specific genetic change called a RET fusion. It involved 223 participants worldwide who had not…

This early-stage study tested a new drug called Felmetatug Vedotin, both alone and combined with pembrolizumab, in people with advanced solid tumors that had spread or could not be removed by surgery. The main goal was to find safe dosage levels and understand side effects for ca…

This was a first-in-human study to test the safety and early signs of effectiveness of a new drug, PF-07284890, for people with advanced solid tumors that have a specific genetic change called a BRAF V600 mutation. The trial enrolled 65 participants with cancers like melanoma, lu…

This study tested an experimental drug called MORAb-202 in people with a specific type of advanced lung cancer that had spread and worsened despite prior treatments. The goal was to see if the drug was safe and if it could shrink tumors. The trial was stopped early and only enrol…

This early-phase study aimed to test the safety, side effects, and best dose of an experimental drug called QEQ278 in adults with advanced solid tumors. It enrolled 30 participants with specific advanced cancers (lung, kidney, esophageal, or head/neck) that had progressed despite…

This early-stage study tested whether combining a new immunotherapy drug (sasanlimab) with other targeted cancer therapies was safe and effective for people with advanced non-small cell lung cancer. The trial involved 34 participants and was designed in two parts, testing differe…

This study tested whether adding an experimental drug called bemcentinib to standard chemotherapy and immunotherapy is safe and effective for people with advanced non-small cell lung cancer. It focused on patients who had not received prior treatment and included a group with a s…

This study tested a personalized treatment plan for patients with multiple early-stage lung tumors. Doctors used genetic sequencing of the tumors to guide a combination of targeted drug therapy and surgery or radiation. The goal was to see if this aggressive, tailored approach co…

This study aimed to see if a new drug called BAT3306 works similarly to the established drug Keytruda, when both are given with standard chemotherapy. It was for adults with advanced, non-squamous non-small cell lung cancer who had not received prior treatment. The main goal was …

This early, terminated study aimed to understand how two experimental cancer drugs travel to and collect in tumors. It involved 8 patients with advanced lung or head/neck cancers. Researchers used a special radioactive tracer and PET scans to take pictures showing where the drugs…