New drug aimed at lung cancer shows promise in early trial
NCT ID NCT05577715
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested an experimental drug called MORAb-202 in 31 people with a type of advanced lung cancer (non-small cell lung cancer adenocarcinoma) that had gotten worse after other treatments. The drug is designed to target and kill cancer cells while sparing healthy ones. The trial was stopped early, but researchers were looking at how safe the drug is and whether it can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- MORAb-202 (Farletuzumab ecteribulin)
- What this could lead to
- If it works, this could point toward a new treatment option for people with a certain type of advanced lung cancer that has stopped responding to other therapies.
- What could go wrong
- This was a small, early-phase trial that was terminated early, so results are limited. The drug may cause side effects and may not shrink tumors or improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
31 people
The number who actually took part.
- Started
-
Nov 2022
- Finished
-
Aug 2024
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Histologically or cytologically documented metastatic NSCLC AC (as defined by the 8th International Association for the Study of Lung Cancer Classification). * Measurable target disease assessed by the investigator according to RECIST 1.1. * Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1 Exclusion Criteria: * NSCLC histologies other than AC (ie, squamous cell carcinoma, large cell carcinoma). * Significant third-space fluid retention (eg, ascites or pleural effusion) that requires repeated drainage. * Prior pneumonectomy. Prior lobectomy and segmentectomy are allowed \> 12 months before treatment. * Recent chest radiotherapy. Participants with chest or chest wall radiation may be permitted if chest radiation is documented \> 6 months before starting study treatment. Other protocol-defined inclusion/exclusion criteria apply.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Henry Ford Hospital
Detroit, Michigan, 48202-2608, United States
-
Local Institution - 0001
Marietta, Georgia, 30060, United States
-
Local Institution - 0002
Kansas City, Missouri, 64132, United States
-
Local Institution - 0005
Louisville, Kentucky, 40241-2832, United States
-
Local Institution - 0007
Orange, California, 92868-3201, United States
-
Local Institution - 0010
Orange City, Florida, 32763-8316, United States
-
Local Institution - 0011
Charlotte, North Carolina, 28207, United States
-
Local Institution - 0012
Ballarat Central, Victoria, 3350, Australia
-
Local Institution - 0014
Toulon, 83056, France
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Local Institution - 0015
Suresnes, 92151, France
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Local Institution - 0017
Rouen, 76000, France
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Local Institution - 0018
Madrid, 28041, Spain
-
Local Institution - 0019
Majadahonda (Madrid), M, 28222, Spain
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Local Institution - 0020
Málaga, MA, 29010, Spain
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Local Institution - 0021
Barcelona, 08036, Spain
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Local Institution - 0022
Murdoch, Western Australia, 6150, Australia
-
Local Institution - 0023
Santiago, 7500921, Chile
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Local Institution - 0025
Barcelona, 08035, Spain
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Local Institution - 0026
Santiago de Compostela, 15706, Spain
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Local Institution - 0027
Recoleta, 8420383, Chile
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Local Institution - 0028
Providencia, SA, 7500653, Chile
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Local Institution - 0030
Independencia, 8380456, Chile
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Local Institution - 0031
Seville, 41013, Spain
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Local Institution - 0033
Fairfax, Virginia, 22031-4629, United States
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Local Institution - 0034
Arlington, Texas, 76012-2510, United States
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Local Institution - 0035
Lone Tree, Colorado, 80124, United States
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Local Institution - 0036
Roeselare, 8800, Belgium
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Local Institution - 0038
Villejuif, 94805, France
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Local Institution - 0039
Mons, WHT, 7000, Belgium
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Local Institution - 0040
Wollongong, NS, 2500, Australia
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Local Institution - 0043
Clermont, Florida, 34711-6699, United States
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Local Institution - 0044
Silver Spring, Maryland, 20904-7917, United States
-
Local Institution - 0045
Flower Mound, Texas, 75028-1713, United States
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Other studies related to the condition(s) this trial covers.
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