BREAST ADENOCARCINOMA

This study is for people with advanced breast cancer who cannot or choose not to have surgery. It tests whether adding radiation therapy to standard medications can shrink the cancer and keep it from getting worse. The goal is to control the disease, not to cure it, and participa…

This study tests a drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to check safety and see if the drug shrinks tumors. About 764 participants with cancers like ovarian, lung, breast, or endometrial cancer will t…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study is for people with breast cancer whose tumors did not shrink after two rounds of standard chemotherapy. Researchers want to see if adding a special type of radiation (SBRT) to the remaining chemotherapy can help eliminate the cancer more effectively. About 96 participa…

This study looks at how skin quality and self-esteem change in breast cancer survivors who are starting a type of hormone therapy called aromatase inhibitors. About 35 women with early-stage breast cancer will join. Researchers will use special imaging to track skin changes and s…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goal is to…

This study tests a high-CBD plant extract (BRC-001) to see if it can reduce joint pain and stiffness in women with breast cancer who take aromatase inhibitors (AIs). AIs lower estrogen to prevent cancer return but often cause arthritis-like side effects, leading some women to sto…

This study looks at how chemotherapy changes certain nerve reflexes that control blood pressure and exercise response in breast cancer patients. Researchers will compare 24 women who recently finished chemotherapy with healthy women of similar age and fitness. The goal is to unde…

This study looks at how a specific gene change (HSD3B1) affects the way postmenopausal women with early-stage, hormone-sensitive breast cancer respond to the drug letrozole before surgery. Researchers will measure changes in tumor markers to see if the gene variant makes the drug…

This study watches how doctors decide on treatments for people with early-stage, hormone-sensitive breast cancer. It includes up to 2,000 participants and follows them for 10 years to see how well they do. The goal is to learn whether a test called EndoPredict helps guide better …

This study looks at blood and tumor samples from 230 adults with HER2-positive breast cancer (stages I-IV) who are starting anti-HER2 drugs like trastuzumab. The goal is to learn how the immune system reacts to these treatments. No new therapy is being tested; instead, researcher…