BREAST ADENOCARCINOMA

This large Phase 3 trial studied nearly 5,000 women with breast cancer that had spread to lymph nodes or was at high risk of returning. Participants received standard chemotherapy (doxorubicin, cyclophosphamide, and paclitaxel) plus either bevacizumab or a placebo. The goal was t…

This study tests whether giving two immunotherapy drugs (decitabine and pembrolizumab) before standard chemotherapy can boost the body's immune attack on HER2-negative breast cancer. About 46 adults with locally advanced disease will receive this short course, then proceed to usu…

This study tested a shorter course of radiation (hypofractionation) for women with breast cancer that has spread to lymph nodes. The goal was to see if this approach reduces long-term side effects like arm swelling (lymphedema) while still controlling cancer. About 137 women part…

This large study looked at over 10,000 women with early-stage, hormone-receptor-positive breast cancer that had not spread to lymph nodes. It used a genetic test called Oncotype DX to find out each woman's risk of the cancer coming back. The goal was to see if women with a mid-ra…

This study tested whether adding the drug entinostat to standard hormone therapy (exemestane) helps people with advanced hormone receptor-positive breast cancer live longer without their cancer growing. About 600 adults with breast cancer that had spread or come back took part. T…

This early-phase study tests the safety and best doses of three drugs—entinostat, nivolumab, and ipilimumab—given together to people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if this combination can help the immune system figh…

This study looks at how well proton beam radiation works for early-stage breast cancer (stages 0 to II) and what side effects it causes. Researchers want to see if this precise type of radiation can kill cancer cells while causing less damage to healthy tissue and improving how t…

This study collects information from multiple hospitals about breast cancer in transgender and gender-diverse adults. Researchers will look at how the cancer was found, what risk factors were present, what treatments were used, and how well patients did over time. The goal is to …

This study looks at whether it is safe for people with breast tissue expanders to have an MRI scan. The main goal is to see if the MRI causes any heating, burning, or pain near the expander. About 68 people will take part, and if at least 50 scans are completed without problems, …