BONE METASTASES

This study tests a new drug called 9-ING-41, given alone or with chemotherapy, in adults with advanced cancers that have stopped responding to standard treatments. The goal is to see if the drug is safe and can help control the cancer. About 350 people with various cancer types, …

This study is for men whose prostate cancer has returned and spread to a few spots (up to 5) in the bones or lymph nodes. It compares standard radiation therapy alone versus radiation plus an immunotherapy drug called durvalumab. The goal is to see if adding the drug helps keep t…

This study tests whether giving denosumab every 12 weeks instead of every 4 weeks is just as effective at preventing bone complications (like fractures or spinal cord compression) in people with metastatic breast or prostate cancer. About 1,380 participants will be followed to co…

This study looks at whether adding a high-dose, precise type of radiation called SBRT to usual treatments (like hormone therapy or chemo) can delay cancer progression in people with 1 to 5 bone metastases from breast, lung, or prostate cancer. About 168 adults aged 18-75 with goo…

This study compares two common blood thinners—aspirin and low molecular weight heparin—to see which works better at preventing dangerous blood clots after surgery for bone or soft tissue cancer in the pelvis or leg. About 2,868 adults who have had or will have such surgery will b…

This study tests whether a special PET scan can predict if the drug T-DM1 will work in people with advanced HER2-positive breast cancer that has spread. Ten women with metastatic breast cancer received a radioactive tracer to see where the drug goes in the body. The goal is to he…

This study tests if a supervised exercise program is safe and helpful for people with painful bone metastases (cancer that spread to bones) after they receive standard radiation therapy. About 20 adults with cancer will take part. The goal is to see if exercise can improve pain, …

This study tests whether focused ultrasound (MR-HIFU), alone or with standard radiation, can better relieve bone pain caused by cancer that has spread. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to see if adding ultras…

This study looks at whether a special PET scan can help doctors see how well hormone therapy is working in breast cancer that has spread to the bones. About 75 adults with estrogen receptor-positive breast cancer and bone metastases will get a PET scan before starting new hormone…

This study aimed to collect medical information from adult cancer patients whose cancer has spread to the bone. The goal was to better understand how and why cancer spreads to bones and how to prevent complications like fractures or pain. No extra tests or visits were required. H…

This study aims to improve how doctors estimate survival for people with cancer that has spread to their bones and who need surgery. Researchers will combine the doctor's assessment with the patient's own health report to see if this gives a more accurate survival prediction than…