BIPOLAR DISORDER (BD)

This study tests a new group program called PEDAL for people with bipolar disorder. It adds digital tools and skills training to standard group education to help manage rapid mood swings. The trial will involve 120 adults in Norway, comparing the new program to the usual group ed…

This study looks at how well people with schizophrenia or bipolar disorder take their long-term medication. Researchers will use pharmacy records to check if online questionnaires accurately measure adherence. Participants with low adherence can join a telehealth program with gro…

This study tests a personalized program combining lifestyle changes (exercise, diet, sleep, social activities), a weight-loss medication (semaglutide) for those who are overweight, and optional brain stimulation for depression. The goal is to improve mental functioning in 140 adu…

This study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can quickly reduce suicidal thoughts in people with treatment-resistant depression and borderline personality disorder. About 120 adults will receive either ketamine or a placebo alon…

This study looks at whether eating only during an 8-hour window each day can help people with bipolar disorder who are overweight and depressed. Forty adults will either follow this eating schedule or stay on a waiting list for 8 weeks. Researchers will check weight, mood, and ot…

This pilot study tests whether a wearable light device (Vielight RX Gamma) aimed at the brain can safely improve symptoms of bipolar depression. Forty adults with bipolar depression will receive either active or sham treatment in clinic five days a week for six weeks. Researchers…

This study tests a noninvasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve memory and thinking in people with bipolar disorder. Researchers will enroll 88 adults with stable bipolar disorder and give them either real or fake…

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes will happen. Researchers will track sleep, movement, and decision-making in 600 people using smartwatches and computer tasks. The goal is to tell bipolar disorder apart from depression…

This study looks at whether Borderline Personality Disorder (BPD) might be better understood as an addiction to relationships, similar to substance use disorders. Researchers will compare 194 people with BPD, bipolar disorder, and healthy volunteers using questionnaires and tests…

This study tests whether changes in a person's voice can help predict upcoming depressive or manic episodes in bipolar disorder. Researchers will collect voice recordings and lifestyle data from 170 adults with bipolar disorder over 6 months. The goal is to develop a model that g…