BILIARY TRACT CANCER

This study tests an experimental drug called XmAb20717 in 27 adults with advanced bile duct cancer that worsened after or could not tolerate standard chemotherapy. The goal is to see if the drug can shrink tumors or slow cancer growth. Participants receive the drug alone, and res…

This study tests whether adding durvalumab to standard chemotherapy helps people with advanced biliary tract cancer (a rare cancer of the bile ducts or gallbladder). About 142 participants will receive the combination as their first treatment. The goal is to see if it improves su…

This study tests whether adding the drug rilvegostomig to standard chemotherapy can help prevent biliary tract cancer from returning after surgery. About 757 adults who had their cancer completely removed will receive either rilvegostomig plus chemo or a placebo plus chemo. The m…

This study tests a combination of chemotherapy (gemcitabine/cisplatin) plus two targeted drugs (trastuzumab and pembrolizumab) as a first treatment for people with HER2-positive bile duct or gallbladder cancer that cannot be removed by surgery. About 24 adults will receive the tr…

This study tests whether combining two immunotherapy drugs (durvalumab and tremelimumab) with radiation therapy can shrink tumors in people with advanced liver cancer or bile duct cancer. About 37 adults whose cancer cannot be removed by surgery or has spread will receive the tre…

This study tests whether adding the experimental drug CTX-009 to standard chemotherapy (paclitaxel) helps adults with advanced bile duct, gallbladder, or ampullary cancer that has worsened after one prior treatment. About 168 participants will be randomly assigned to receive eith…

This phase 3 study tests whether a new drug called AK112, combined with standard chemotherapy, works better than another drug (durvalumab) plus the same chemo for people with advanced bile duct cancer that cannot be removed by surgery. About 682 participants will receive either A…

This study was planned to test two drugs, Ezabenlimab and BI 907828, in people with advanced solid tumors like sarcoma, lung, breast, colorectal, or bile duct cancer. The goal was to see if the combination could control tumor growth for at least 24 weeks. However, the study was w…

This study tests two drugs, candonilimab and LM-302, in people with advanced biliary tract cancer that has not responded to standard chemotherapy and immunotherapy. The goal is to see if the combination can shrink tumors or slow the disease. About 78 adults with a specific protei…

This early-stage study tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can reduce depression and anxiety in people with advanced pancreatic, biliary, or other gastrointestinal cancers. 24 participants and their family members are involved. The…

This study tests whether a small monitoring probe placed near the surgical site can detect internal leaks early after pancreatic cancer surgery. About 200 adults having this operation will be randomly assigned to receive the probe or standard care. The goal is to see if early det…