Barrett esophagus
Clinical trials for Barrett esophagus explained in plain language.
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New acid blocker may offer stronger reflux control for Barrett's esophagus
Disease control Not yet recruitingThis study tests whether vonoprazan, a newer type of acid-suppressing medication, reduces acid reflux in the esophagus better than standard proton pump inhibitors (PPIs) in people with Barrett's esophagus. Participants will first take their usual PPI for a week, then switch to vo…
Matched conditions: BARRETT ESOPHAGUS
Phase 4 • Sponsor: University of North Carolina, Chapel Hill • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Sponge on a string and AI could revolutionize esophageal cancer screening
Diagnosis Not yet recruitingThis study will test whether a combination of an AI-powered risk tool, a simple 'sponge on a string' test, and nurse navigation can improve screening for Barrett's esophagus and esophageal cancer. Over 1,000 adults at higher risk will be enrolled. The goal is to see if these less…
Matched conditions: BARRETT ESOPHAGUS
Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 14:02 UTC
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Can a Pre-Surgery checklist predict who will still have reflux after fundoplication?
Knowledge-focused Not yet recruitingLaparoscopic fundoplication relieves reflux for most GERD patients, but 10 to 30 percent still have symptoms or side effects afterward. Researchers at Minia University Hospitals follow 470 adults scheduled for this keyhole surgery, measuring ten factors before the operation such …
Matched conditions: BARRETT ESOPHAGUS
Sponsor: Minia University • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC
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Spit test may spot reflux risk after gastric sleeve surgery
Knowledge-focused Not yet recruitingThis study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…
Matched conditions: BARRETT ESOPHAGUS
Sponsor: Hospital de Mataró • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Genetic risk profiles could change how we monitor Barrett's esophagus
Knowledge-focused Not yet recruitingThis study looks at whether sharing genetic risk information with Barrett's esophagus patients can improve their quality of life and reduce cancer worry. Researchers will collect tissue samples and use genetic analysis to create risk profiles. Half of the 266 participants will le…
Matched conditions: BARRETT ESOPHAGUS
Sponsor: University Hospital, Antwerp • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC