Genetic risk profiles could change how we monitor Barrett's esophagus
NCT ID NCT07455422
First seen Mar 25, 2026 · Last updated Jun 22, 2026 · Updated 12 times
Summary
This study looks at whether sharing genetic risk information with Barrett's esophagus patients can improve their quality of life and reduce cancer worry. Researchers will collect tissue samples and use genetic analysis to create a risk model. 266 participants will be randomly assigned to either learn their risk profile or not, and all will undergo more frequent monitoring than usual.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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AZ Delta
Roeselare, Belgium, 8800, Belgium
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Antwerp University Hospital
Edegem, Antwerpen, 2650, Belgium
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CHU LILLE - Centre Hospitalier Universitaire de Lille
Lille, 59000, France
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Ghent University Hospital (UZ Gent)
Ghent, Belgium, 9000, Belgium
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IRCCS Ospedale San Raffaele
Milan, Milano, 20132, Italy
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Karolinska University Hospital
Solna, SE-171 76, Sweden
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Rigshospitalet
Copenhagen, 2100, Denmark
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Sint-Augustinus Hospital (ZAS)
Wilrijk, Antwerpen, 2610, Belgium
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St James's Hospital
Dublin, D08 NHY1, Ireland
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University Hospital Leipzig
Leipzig, Leipzig, 04103, Germany
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What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could lead to more personalized and cost-effective surveillance strategies for Barrett's esophagus patients, reducing unnecessary procedures and anxiety.
What could go wrong
This is an early-stage observational study, not testing a treatment. The risk model may not prove accurate enough to change practice, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.