Autoimmune hepatitis

This study looks at whether a plant-based (vegan) diet can help children with autoimmune hepatitis achieve disease remission. Researchers will compare a vegan diet to a standard high-protein diet over 180 days in 40 newly diagnosed children. The goal is to see if diet changes can…

This study tests whether adding belimumab to standard therapy can better control autoimmune hepatitis, a chronic liver disease. About 48 adults with active or stable disease will receive weekly injections for 72 weeks. The goal is to reduce liver inflammation and lower the need f…

This early study tests whether siplizumab, given at the time of liver transplant, can safely prevent the immune system from attacking the new liver. Up to 8 adults with autoimmune hepatitis or primary sclerosing cholangitis will receive two doses. The main goal is to check for se…

This study evaluates whether a blood test measuring polyreactive immunoglobulin G (pIgG) can more accurately diagnose autoimmune hepatitis (AIH) and distinguish it from other liver conditions. Researchers will collect blood samples from 400 adults undergoing liver biopsy for susp…

This study compares a Mediterranean diet to a Western diet to see which one better reduces fatigue in people with autoimmune hepatitis. About 48 adults will try both diets in a random order. Researchers will measure changes in fatigue and quality of life using a standard question…

This study follows 150 young people (ages 6-23) with autoimmune liver disease to see if MRI scans can predict how their condition will progress over the next decade. Participants will have MRI scans at the start and again at one and two years, while their clinical health is track…

This study creates a shared registry and learning network for children and young adults with autoimmune liver disease, including autoimmune hepatitis and primary sclerosing cholangitis. By collecting clinical data across multiple centers, the goal is to reduce treatment variation…

This study is testing whether MRI scans can accurately detect bile duct damage and liver scarring in young people aged 6 to 23 with autoimmune liver diseases like primary sclerosing cholangitis and autoimmune hepatitis. Researchers will compare MRI results with traditional liver …

This study looks at the gut bacteria of 3000 adults with chronic liver diseases like autoimmune hepatitis and fatty liver. Researchers want to find specific bacteria linked to each disease to better understand how the gut and liver interact. This is an observational study, not a …