ARDS

This study tests an experimental drug called paridiprubart in adults hospitalized with moderate-to-severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival…

This study tests whether a drug called bevacizumab can help adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo, and researchers will track survival rates and oxygen levels.…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either an active drug or a placebo to see if the treatments improve survival and are safe. The ma…

This study looks at whether using higher pressure during noninvasive breathing support (a mask that helps you breathe) can help people with pneumonia or acute lung injury avoid needing a breathing tube. About 700 adults will be randomly assigned to either high or low pressure. Th…

This study tests a special blood filter (HA380) in 40 very ill adults who need dialysis or a heart-lung machine. The filter is designed to remove harmful inflammatory substances from the blood. Researchers want to see if using the filter is practical and if it can reduce time on …

This study tests whether setting a breathing machine based on each patient's lung mechanics can lower the chance of death by day 60 in people with acute respiratory distress syndrome (ARDS). About 740 adults with moderate to severe ARDS, including those with COVID-19, will take p…

This study looks at two ways of feeding patients with severe lung injury (ARDS) who are lying on their stomachs and on a breathing machine. It compares feeding through a tube in the stomach versus one in the small intestine. The goal is to see which method helps patients get bett…

This Phase 3 trial tests whether a treatment called ExoFlo, made from stem cell particles, can help hospitalized adults with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), a serious lung condition. About 970 participants will receive either ExoFlo or a placebo thr…

This study tests a drug called vilobelimab in adults hospitalized with severe lung failure (ARDS). About 200 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces deaths within 28 days.

This study checks whether standard devices that measure blood flow and fluid needs work correctly in patients on ECMO, a machine that pumps and oxygenates blood outside the body. About 30 adults with severe lung failure will be enrolled. The goal is to improve how doctors manage …

This study checks how well standard ICU monitors measure blood flow and fluid needs in 30 adults on VA-ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three monitoring methods to see which works best during this special situation. The go…

This study is watching 1,000 ICU patients to find early signs in their bodies that could help doctors diagnose life-threatening conditions like sepsis and ARDS sooner. The goal is to learn which patients might benefit from specific treatments and to discover new therapies. No exp…

This study looks at how changing the pressure in a ventilator affects lung function in people with severe breathing problems (ARDS). Researchers will test two different pressure levels in 50 patients to see which works better for different types of lung stiffness. The goal is to …

This study tests whether a personalized lung inflation technique can improve heart and lung function in two groups of children on breathing machines: those recovering from heart surgery and those with severe respiratory failure. Researchers will measure how well the lungs and hea…

This study looks back at medical records of about 60 ICU patients who received a treatment called low-flow ECCO2R, which helps remove carbon dioxide from the blood when the lungs are failing. Researchers want to describe how the therapy is used in practice and what outcomes patie…

This study tests a computer decision-support tool that helps doctors choose the best ventilator settings for children with acute respiratory distress syndrome (ARDS). The tool is based on the latest evidence and aims to reduce lung damage and time on the breathing machine. Up to …

This study looks back at medical records of 200 people with severe lung failure (ARDS) to see if their immune system affects their risk of getting extra infections. Researchers will check for reactivation of viruses like herpes and measure different immune cells. The goal is to f…

This study observes 134 adults having chest surgery to see if the time one lung is deflated (single-lung ventilation) is linked to lung complications like pneumonia or breathing trouble. Researchers will track ventilation time and check for problems within a week after surgery. T…

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…