ALCOHOLISM

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either the drug or a placebo for 16 weeks, and researchers will track thei…

This study tests whether a monthly injection of naltrexone (a medication that blocks pleasure from alcohol) helps people who drink mainly for the rewarding effects reduce their heavy drinking. About 60 adults with alcohol use disorder will receive either the shot or a placebo, pl…

This study tests a non-invasive brain stimulation device called Deep TMS to see if it can help people with moderate to severe alcohol use disorder drink less. About 186 adults aged 18-86 will either get real or fake (sham) stimulation over several weeks. The main goal is to see i…

This study tests whether offering specialized alcohol use treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease quit drinking. About 221 adults will be randomly assigned to either receive the alcohol treatment offer or standard care. …

This study is testing whether a combination of ketamine (a medicine) and real-time brain training (neurofeedback) can help people with alcohol use disorder drink less. About 75 adults who want to reduce or stop drinking will receive either ketamine or a placebo, along with real o…

This study tests whether adding cannabidiol (CBD) to the standard medication naltrexone can better reduce alcohol cravings in people with alcohol addiction. About 150 adults who experience strong cravings will receive either a high dose of CBD plus naltrexone, a lower dose of CBD…

This study aims to build a large data repository by collecting smartphone data and daily surveys from 10,000 adults who use alcohol or drugs. Participants use an app that tracks phone activity and location, and answer questions about mood and substance use. The goal is to underst…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce suicidal thoughts and improve quality of life. About 130 English-speaking adults with bip…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. No trea…

This study follows up to 10,000 medical students in Orleans, France, for up to 22 years to understand what leads to depression and other mental health problems. Researchers will compare students who enter medical school with those who don't, using yearly questionnaires. The goal …

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with alcohol use disorder and healthy volunteers. Participants will complete tasks either inside or outside an MRI scanner to see how the brain works. The goal is to d…