ADVANCED MALIGNANT NEOPLASM

This early-stage trial tests a new drug called ziftomenib (KO-539) in people whose acute myeloid leukemia (AML) has returned or not responded to standard treatments. The study aims to find the safest and most effective dose, and to see if the drug can shrink or control the cancer…

This study tests an experimental drug called vimseltinib in people with a rare joint tumor (TGCT) or advanced solid tumors. The goal is to find the safest dose and see if it shrinks tumors or improves symptoms. About 120 adults will take part. This is not a cure – the drug aims t…

This early-phase study tests a portable device that creates electric fields to disrupt cancer cell growth, combined with chemotherapy and a targeted antibody, in people whose cancer has spread to the liver and hasn't responded to standard treatments. The main goal is to find the …

This study tests a drug called talazoparib in 150 adults whose advanced cancer has stopped responding to standard treatments. The drug works by blocking an enzyme that helps tumor cells survive, and is given to people whose tumors have specific changes in BRCA or related genes. T…

This study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in advanced cancer patients in a palliative care unit. About 70 participants will receive the drugs and be monitored for 24 hours. The goal is …

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce cancer-related fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethason…

This study tests a procedure called cordotomy to reduce severe pain in people with advanced cancer. Using a needle guided by CT scans, doctors target nerves in the spinal cord to block pain signals. The trial includes 27 adults with uncontrolled pain on one side of the body below…

This study looks at whether a medication called methylphenidate (often used for ADHD) combined with physical activity can help reduce severe tiredness in people with advanced cancer who are receiving immunotherapy. About 212 patients with metastatic cancer will take part. The goa…

This study tests two different information sheets to see which one helps advanced cancer patients and their caregivers communicate better with their doctors. About 207 patients and their caregivers will use either a question prompt sheet or a general information sheet during thei…

This study looks at whether cancer patients and their caregivers prefer to wait in an exam room or a waiting room when they visit a supportive care clinic. Researchers will ask about their preferences to understand how to make visits more comfortable. About 406 people with advanc…

This study looks at how serious money problems are for people with advanced cancer. Cancer care can be very expensive, and the stress from debt and high costs may make physical symptoms and quality of life worse. About 141 patients will fill out a short survey to measure their fi…