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Exercise plus steroid pill may fight cancer fatigue

NCT ID NCT02491632

Symptom relief Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along with exercise guidance. The goal is to see which combination improves energy levels and quality of life more effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

90 people

The number who actually took part.

Started

Aug 2015

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A diagnosis of advanced cancer (defined as metastatic or recurrent) with fatigue \>= 4/10 (0-10 scale) on the Edmonton Symptom Assessment Scale (ESAS) * The presence of fatigue for at least 2 weeks * Normal cognition * Hemoglobin \> 8 g/L within 1 week of enrollment in the study * A life expectancy of \>= 4 months * No evidence of significant anxiety or depression as determined by a total HADS scores of \< 21 * Definition of advanced cancer includes those patients who have metastatic or refractory disease according to their treating oncologist * Patients must be able to understand, read, write, and speak English or Spanish Exclusion Criteria: * Patients with a history of hypersensitivity to dexamethasone or having any contraindication to physical activity as determined by the treating physician * Reports a fall in the past 30 days * Uncontrolled diabetes mellitus as defined by a random blood sugar of \> 200 mg/dl not being monitored by their primary care physician * Sepsis and/or acute, chronic, or ongoing infections that are currently being treated with systemic antimicrobials * Will exclude patients with current, active peptic ulcer disease * Neutropenia as defined by an absolute neutrophil count (ANC) of \< 1000 cells/mm * Regular participation in moderate- or vigorous-intensity physical activity for \>= 30 minutes at least 5 times a week and strength training for \>= 2 days * Severe cardiac disease (New York Heart Association functional class III or IV) or coronary artery disease

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Conditions

The condition(s) this trial relates to.

cancer Fatigue metastatic malignant neoplasm neoplasm Neoplasm Metastasis Recurrence refractory malignant neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Advanced malignant neoplasm Fatigue Metastatic malignant neoplasm Recurrent malignant neoplasm Refractory malignant neoplasm

Contacts and locations

Locations

  • M D Anderson Cancer Center

    Houston, Texas, 77030, United States

More trials for these conditions

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