ADENOID CYSTIC CARCINOMA

This study tests whether a combination of two drugs (becotatug vedotin and epirubicin) can shrink a rare type of sinus cancer that has come back and cannot be surgically removed. About 40 adults with EGFR-positive adenoid cystic carcinoma will receive the treatment to see if it m…

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find a safe dose and check for side effects. About 319 participants will receive the drug to see…

This early-stage study tests a new drug called RGT-61159 in people with adenoid cystic carcinoma or colorectal cancer that has returned or stopped responding to standard treatments. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors…

This study tests whether giving a precise, high-dose radiation treatment (SBRT) early can slow the growth of adenoid cystic carcinoma that has spread to a few spots in the body. About 32 adults with 1 to 5 metastatic lesions will receive SBRT to all visible tumors. Researchers wi…

This study tests a new drug called REM-422 in about 100 people with advanced adenoid cystic carcinoma (ACC), a rare cancer of the glands. The drug works by breaking down a specific genetic message (MYB) that helps the cancer grow. The main goals are to check the drug's safety and…

This early-phase study tests a new drug called NN3201, designed to find and attack cancer cells that have a specific protein called c-Kit. The trial includes people with advanced or spreading cancers like gastrointestinal stromal tumors (GIST), small-cell lung cancer, and others.…

This study is for people with a rare and hard-to-treat sinus cancer called sinonasal adenoid cystic carcinoma. Researchers are testing a method where a high dose of the chemotherapy drug epirubicin is delivered directly to the tumor through a small tube in an artery. After three …

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another drug (pembrolizumab), in people with advanced solid tumors or lymphoma that have stopped responding to standard treatments. The goal is to find a safe dose and see if it can shrink…

This phase II trial tests a new drug called puxitatug samrotecan (AZD8205) in 28 adults with an aggressive, advanced form of adenoid cystic carcinoma (ACC-I). The study aims to see if the drug is safe and can control the cancer. Participants must have a specific genetic mutation …

This study tests a drug called enfortumab vedotin in people with adenoid cystic carcinoma (ACC) that has spread or come back. The goal is to see if the drug can shrink tumors and how safe it is. About 34 adults with ACC will take part, and researchers will track tumor response an…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control tumors for at least 12 months. About 28 adults who have not responded to standard treatments will take part.