ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Clinical trials for ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME explained in plain language.
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New chemo cocktail aims to keep leukemia from coming back after transplant
Disease control OngoingThis study tests whether giving two chemotherapy drugs (clofarabine and melphalan) before a donor stem cell transplant can help prevent leukemia from returning in patients whose cancer is in remission. The approach aims to kill any remaining cancer cells and stop the immune syste…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated May 26, 2026 09:07 UTC
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New drug combo shows promise for blood cancers, but cure not yet in sight
Disease control OngoingThis study tests two drugs, vorinostat and azacitidine, together in people with myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML). The goal is to find the safest dose and see how well the combination works at controlling the disease. About 135 adults with these bloo…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE1, PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 09:06 UTC
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New combo tackles tough blood cancers in early trial
Disease control OngoingThis study tests a combination of two chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in about 50 adults with acute myeloid leukemia (AML) that has returned or not responded to treatment, or with high-risk myelodysplastic syndrome (MDS). The goal is to see if the combinati…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 08:59 UTC
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Immunotherapy boosts leukemia remission in older patients?
Disease control OngoingThis study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (azacitidine and venetoclax) helps older adults with newly diagnosed acute myeloid leukemia (AML) achieve deeper remissions and lower the chance of the cancer returning. About 60 participan…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 08:57 UTC
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Could a targeted drug boost chemo for tough blood cancers?
Disease control OngoingThis study tested whether adding the drug veliparib to standard chemotherapy helps people with advanced blood cancers like acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML). About 25 adults took part. The goal was to see if the combination improved response …
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 26, 2026 08:32 UTC
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New antibody takes aim at Hard-to-Treat blood cancers
Disease control OngoingThis early-phase study tests a new antibody called Hu8F4 in 72 people with advanced blood cancers like leukemia and myelodysplastic syndrome. The main goal is to find a safe dose and check for side effects. Researchers hope the antibody can slow or stop cancer growth.
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated May 26, 2026 08:19 UTC
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New drug cocktail shows promise for tough leukemia in younger patients
Disease control OngoingThis study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other bone marrow diseases or cancer treatments. The goal is to see how many patients achieve complete remission. 21 particip…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated May 22, 2026 14:03 UTC
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New hope for tough blood cancers: targeted drug shows promise in early trial
Disease control OngoingThis study tests a drug called olaparib in 14 adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has returned or not responded to treatment, and who have a specific change in the IDH gene. The drug works by blocking enzymes that cancer cells need to g…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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Immunotherapy boosts standard chemo in AML trial
Disease control OngoingThis study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) achieve deeper remission. About 49 adults with AML, including those whose cancer arose from prior conditions, will receive …
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 20, 2026 11:57 UTC
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New combo therapy aims to stabilize AML longer
Disease control OngoingThis early-phase trial studies the safety and best dose of navtemadlin when added to standard chemotherapy (cytarabine and idarubicin) for people with newly diagnosed acute myeloid leukemia (AML). Navtemadlin blocks a protein that helps cancer cells grow. The goal is to see if th…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 19, 2026 11:49 UTC
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New hope for tough leukemia: drug combo shows promise in early trial
Disease control OngoingThis study tests a new drug called pevonedistat alongside standard chemotherapy for people with a high-risk type of acute myeloid leukemia (AML). The goal is to see if the combination is safe and works better at getting the cancer into remission. About 53 adults with newly diagno…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE1, PHASE2 • Sponsor: University of Southern California • Aim: Disease control
Last updated May 19, 2026 11:46 UTC
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Talking therapy tested to fight exhaustion in blood cancer patients
Symptom relief OngoingThis study looks at whether cognitive behavioral therapy (CBT) can help people with acute myeloid leukemia (AML) or lymphoma who feel very tired from their cancer or treatment. About 48 patients will take part in up to 7 counseling sessions to learn new ways to cope with fatigue.…
Matched conditions: ACUTE MYELOID LEUKEMIA ARISING FROM PREVIOUS MYELODYSPLASTIC SYNDROME
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated May 19, 2026 11:47 UTC