X-linked mixed hearing loss with perilymphatic gusher
MONDO:0010576X-linked mixed deafness with perilymphatic gusher, also known as X-linked deafness type 2, is a rare form of non-syndromic genetic deafnesss affecting males and characterized by pathognomonic inner ear anomalies and conductive and profound sensorineural hearing loss. The inner ear anomalies are described as dilatation of the internal auditory meatus and fistulous connection between the cochlear basal turn and internal auditory canal resulting in perilympatic gusher on attempted mobilization of a fixed stapes. Obligate female carriers may suffer from mild to moderate hearing loss.
Also known as: central hearing loss, high frequency deafness, high frequency hearing loss, high-frequency hearing loss, perceptive deafness, perceptive hearing loss, perceptive hearing loss or deafness, sensorineural deafness
34 clinical trials for this condition and its sub-types, 32 tagged with X-linked mixed hearing loss with perilymphatic gusher itself.
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New cochlear implant aims to help those with partial hearing hear better
Disease control CompletedThis study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …
Sponsor: Cochlear • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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Could a Child's own cord blood stem cells restore hearing?
Disease control CompletedThis study tests whether infusing a child's own stored umbilical cord blood stem cells is safe for children with acquired sensorineural hearing loss. The trial enrolls children with moderate to profound hearing loss and aims to see if the infusion can improve inner ear function, …
Phase 1 • Sponsor: James Baumgartner, MD • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Could talking it out boost hearing aid success?
Symptom relief CompletedThis trial tests whether communication training helps first-time hearing aid users with mild to moderate hearing loss adapt better. Participants receive training either in a group or one-on-one, and researchers compare their hearing-related quality of life, communication strategi…
Sponsor: University Ghent • Aim: Symptom relief
Last updated Sep 03, 2026 00:00 UTC
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Can a simple supplement quiet tinnitus and save your hearing?
Symptom relief CompletedThis study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…
Sponsor: Keep Hearing, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Acupuncture meets modern medicine: can a herb injection ease hearing loss and vertigo?
Symptom relief CompletedThis completed study tested whether adding gastrodin acupoint injections to standard care helps people with sudden hearing loss and vertigo. One hundred adults received either standard therapy alone or standard therapy plus injections into specific acupuncture points over four we…
Sponsor: The First Hospital of Hebei Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Scientists hunt for genes behind hearing loss and dizziness
Knowledge-focused CompletedThis study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for genes behind inner ear malformation
Knowledge-focused CompletedThis study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…
Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD) • Aim: Knowledge-focused
Last updated Aug 06, 2026 00:00 UTC
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Electrical fingerprints may reveal hidden scarring in cochlear implant patients
Knowledge-focused CompletedThis study investigates whether a quick, painless electrical measurement called transimpedance matrix (TIM) can detect scar tissue (fibrosis) that sometimes forms inside the cochlea after cochlear implant surgery. Researchers will compare TIM results with CT scans in 180 adults w…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jul 11, 2026 00:00 UTC
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Simple signs and amplifiers may cut hospital delirium
Knowledge-focused CompletedThis study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Inner ear secrets: study aims to predict who will hear better with hearing aids
Knowledge-focused CompletedThis completed study enrolled 186 people with mild to moderate hearing loss to understand how damage to inner ear sensory cells and auditory neurons affects speech understanding, especially in noisy environments. Participants were fitted with hearing aids and tested on speech rec…
Sponsor: Steward St. Elizabeth's Medical Center of Boston, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC