Uveitis

Researchers are testing whether adalimumab biosimilars combined with immunosuppressive drugs work as well as corticosteroids combined with immunosuppressants for adults with noninfectious intermediate, posterior, or panuveitis. The trial enrolls about 128 people aged 18 to 70 who…

This study followed 30 uveitis patients who received a fluocinolone acetonide implant to control eye inflammation. Researchers used advanced imaging (OCT, OCTA, fluorescein angiography) to track changes in inflammation over 12 months. The goal was to see if imaging could better m…

This study tested whether a weekly injection of abatacept (Orencia) plus usual care could prevent juvenile idiopathic arthritis (JIA) from spreading to more joints or causing eye inflammation. 121 children with recent-onset JIA affecting 4 or fewer joints took part. The goal was …

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This study tested ACTH gel, given as a shot under the skin, in 28 people with non-infectious uveitis (eye inflammation not caused by an infection). The goal was to see if it is safe and can help control inflammation. Participants received one of two doses, and researchers tracked…

This study tested three biologic drugs—adalimumab, anakinra, and tocilizumab—in 112 people with severe, treatment-resistant uveitis, an inflammatory eye disease that can cause blindness. Participants received one of the drugs for 16 weeks. The goal was to see which drug best redu…

This small study tested ustekinumab, a drug that calms the immune system, in 16 adults with Behçet disease. The goal was to see if it could reduce mouth ulcers and eye inflammation. The trial is complete, but because it's early and small, we don't yet know if the drug will become…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

This study tested a new method called metagenomic deep sequencing (MDS) to find the cause of eye infections. 100 adults with suspected infectious uveitis or endophthalmitis were randomly assigned to have their doctors receive MDS results or not, in addition to standard tests. The…

This study tested whether a smartphone meditation app (Calm Health) could help reduce anxiety and depression in 100 adults with non-infectious uveitis, an inflammatory eye disease. Participants used the app and reported their symptoms. The goal was to see if digital mindfulness c…

This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was g…

This study collected blood, saliva, and eye fluid samples from 343 people with uveitis, an inflammatory eye disease that can cause vision loss. Researchers aimed to learn which genes and other factors might lead to the disease and affect treatment response. Participants were foll…

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was…

This study looked at 905 people with uveitis, an eye inflammation, to see if a standardized step-by-step diagnostic plan works as well as letting doctors choose any tests they want. The goal was to find the cause of the uveitis more efficiently and at a lower cost. Researchers co…