Uremia

This study tests a special dialysis machine, the MultiFiltratePRO, in children with acute kidney failure. The goal is to see if it can deliver at least 80% of the prescribed treatment within 72 hours while being safe. About 43 children weighing between 8 and 40 kilograms will be …

This trial explores whether starting dialysis twice a week instead of the standard three times a week, with a gradual increase over a year, can improve quality of life and preserve remaining kidney function in veterans with advanced kidney disease. Participants are randomly assig…

This study tests whether a 12-week course of a multi-species synbiotic supplement can lower harmful gut toxins and reduce inflammation in adults on hemodialysis. About 30 participants will take the supplement and have their blood and urine levels of toxins and inflammatory marker…

This study is testing whether a 12-week course of a multi-species synbiotic (a mix of probiotics and prebiotics) can improve gut health and reduce harmful toxins in the blood of people on hemodialysis. The trial will enroll 30 adults who have been on dialysis for at least 3 month…

This trial tests a device called JuxtaFlow that applies mild suction to the kidneys during heart surgery. The goal is to see if it can protect kidney function in people with pre-existing kidney problems. 124 adults undergoing heart surgery with a heart-lung machine will be random…

This study tests whether special filters (sorption technologies) can lower inflammation in people on long-term hemodialysis for kidney failure. About 60 adults with high inflammation levels will receive the filter during their regular dialysis sessions. The main goal is to see if…

This study tests whether a new intravenous drug, Anrikefon, can improve sleep quality better than a standard oral medication (nalfurafine) in people with chronic kidney disease who suffer from severe itching and are on hemodialysis. Fifty adults will receive either Anrikefon inje…

This study looks at whether adding a blood-filtering step called hemoadsorption to regular dialysis can help people with kidney failure who still have bothersome symptoms like itching, tiredness, and trouble sleeping. Researchers will follow 120 adults for 6 months, tracking how …

This study looks at whether dipyridamole, a drug usually used for heart conditions, can reduce the uncomfortable urge to move the legs in people with kidney failure who are on dialysis. About 80 adults will take the drug three times a day for 12 weeks. Researchers will measure ch…

This study tests a single dose of hydroxynidone capsules in 56 people with different levels of kidney function and healthy volunteers. The goal is to see how the drug moves through the body and if it is safe in people with kidney problems. Participants will have blood and urine t…

This study looks at how a new cholesterol-lowering tablet, HRS-1301, behaves in people with mild, moderate, or severe kidney problems compared to healthy volunteers. The goal is to understand if kidney function changes how the drug works, so doctors can give the right dose. About…

This study reviews medical records from over 50,000 critically ill patients to see if starting dialysis earlier helps them live longer. Researchers will compare patients who started dialysis early versus late, looking at survival up to 90 days and beyond. The goal is to find the …