Trigeminal neuralgia
MONDO:0008599Trigeminal neuralgia is a nerve disorder that causes a stabbing or electric-shock-like pain in parts of the face. The pain lasts a few seconds to a few minutes, and usually on only one side of the face. It can also cause muscle spasms in the face the same time as the pain. The pain may result from a blood vessel pressing against the trigeminal nerve (the nerve that carries pain, feeling, and other sensations from the brain to the skin of theface), as a complication of multiple sclerosis, or due to compression of the nerve by a tumor or cyst. In some cases, the cause is unknown. Treatment options include medicines, surgery, and complementary approaches.
Also known as: neuralgia of trigeminal nerve, trigeminal nerve neuralgia, trigeminal neuralgia, Tic douloureux
46 clinical trials for this condition and its sub-types, 37 tagged with Trigeminal neuralgia itself.
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Can an IV Anti-Seizure drug calm the lightning bolts of trigeminal neuralgia?
Symptom relief Recruiting nowTrigeminal neuralgia causes sudden, severe facial pain that can send people to the emergency department. This observational study at a Spanish hospital follows 20 adults who receive intravenous lacosamide, an anti-seizure drug, as a rescue treatment for a pain flare. Researchers …
Sponsor: Hospital Universitari de Bellvitge • Aim: Symptom relief
Last updated Sep 17, 2026 00:00 UTC
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New combo therapy aims to calm face pain attacks
Symptom relief Recruiting nowThis early-stage study tests whether an injection of RP-008 followed by a daily varenicline pill is safe and can reduce pain for people with trigeminal neuralgia, a condition causing severe facial pain attacks. About 24 adults aged 18-80 with classic or idiopathic trigeminal neur…
Phase 1/2 • Sponsor: Kriya Therapeutics, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 13:05 UTC
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Burst of hope: new brain stimulation tackles stubborn pain
Symptom relief Recruiting nowThis study tests a new type of deep brain stimulation called 'Burst-DBS' for people with long-term facial pain or pain after a stroke. Twenty adults will have electrodes placed in the thalamus (a pain-related brain area) and try both standard and burst stimulation patterns. The g…
Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could early radiation zap away facial pain for good?
Symptom relief Recruiting nowThis study tests whether giving Gamma Knife radiation early—within 2 years of diagnosis—can provide better pain relief for trigeminal neuralgia than waiting. About 80 adults with classic or idiopathic TN will be assigned to early treatment or standard care. Researchers will track…
Phase 2 • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Botox vs. placebo: new hope for face pain sufferers?
Symptom relief Recruiting nowThis study tests whether Botox injections into the skin can reduce the number of painful attacks in people with trigeminal neuralgia, a severe facial pain condition. It includes 20 adults who have not gotten enough relief from medications or are not candidates for surgery. Partic…
Phase 4 • Sponsor: Stanford University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Massive study aims to predict brain surgery success
Knowledge-focused Recruiting nowThis study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:02 UTC
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Massive study aims to unlock secrets of debilitating head pain
Knowledge-focused Recruiting nowThis study is gathering information from 1,500 people with cluster headache or trigeminal neuralgia to learn more about these painful conditions. Researchers will collect surveys, genetic samples, and other health data. The goal is to better understand what causes these headaches…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Nerve signals may guide better pain surgery for face shock pain
Knowledge-focused Recruiting nowThis study looks at whether measuring nerve signals during a procedure called rhizotomy can help treat trigeminal neuralgia, a condition that causes sudden, shock-like facial pain. Researchers will test a monitoring technique in 30 adults already scheduled for the surgery. The ma…
Early phase 1 • Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Nerve zap study aims to sharpen pain procedure
Knowledge-focused Recruiting nowThis study is testing whether measuring nerve signals during a standard procedure for trigeminal neuralgia (a type of severe facial pain) can help doctors target the treatment more precisely. About 30 adults scheduled for the procedure will have their nerve responses recorded fro…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC