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Thrombophilia
MONDO:0002305A condition characterized by an abnormally high level of thrombi. Causes include thrombotic thrombocytopenic purpura, disseminated intravascular coagulation, bone marrow disorders, and antiphospholipid antibody syndrome.
Also known as: excessive blood clotting, hypercoagulability, hypercoagulability state, hypercoagulable
78 clinical trials for this condition and its sub-types, 12 tagged with Thrombophilia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Thrombophilia
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Inherited thrombophilia 0 trials · 28 incl. sub-types
12 sub-types
- Thrombophilia due to thrombin defect 19 trials
- Thrombophilia due to activated protein C resistance 5 trials
- Hereditary antithrombin deficiency 3 trials
- Hereditary thrombophilia due to congenital protein C deficiency 1 trial Sub-types →
- Factor 5 excess with spontaneous thrombosis 0 trials
- Heparin cofactor 2 deficiency 0 trials
- Hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency 0 trials
- Hereditary thrombophilia due to congenital protein S deficiency 0 trials Sub-types →
- Thrombomodulin-related bleeding disorder 0 trials
- Thrombophilia, X-linked, due to factor 8 defect 0 trials
- Thrombophilia, X-linked, due to factor 9 defect 0 trials
- Thrombophilia, familial, due to decreased release of tissue plasminogen activator 0 trials
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Thrombotic thrombocytopenic purpura 15 trials · 20 incl. sub-types
2 sub-types
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Disseminated intravascular coagulation 15 trials
2 sub-types
- Disseminated intravascular coagulation in newborn 0 trials
- Purpura fulminans 0 trials Sub-types →
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Protein S deficiency 3 trials
1 sub-type
Most studied deeper sub-types
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Real-world study examines caplacizumab for aTTP: better treatment on the horizon?
Disease control OngoingThis study looks back at how doctors in Germany prescribed caplacizumab (Cablivi) for acquired thrombotic thrombocytopenic purpura (aTTP), a rare blood clotting disorder. Researchers will analyze data from 350 patients to see how well the drug works outside of clinical trials and…
Sponsor: University of Cologne • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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New enzyme replacement therapy aims to stop dangerous blood clots in rare disease
Disease control OngoingThis study tests a medicine called TAK-755 in people with a rare inherited blood disorder called congenital thrombotic thrombocytopenic purpura (cTTP). The condition causes dangerous blood clots and bleeding. TAK-755 replaces a missing enzyme to help prevent or treat these episod…
Phase 3 • Sponsor: Takeda • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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New combo attack: surgery and drugs take on tough liver cancer
Disease control OngoingThis phase 3 trial is testing whether liver surgery followed by two drugs (atezolizumab and bevacizumab) can help people with liver cancer that has spread into veins. The study includes 501 participants who have not had prior treatment. The goal is to see if this approach delays …
Phase 3 • Sponsor: Jia Fan • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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AI plus ultrasound could catch heart and lung decline before it turns critical
Diagnosis By invitation onlyResearchers are testing whether artificial intelligence can combine ultrasound images with routine health data to track changes in a person's physiology over time. The study enrolls adults with heart, lung, kidney, or blood vessel conditions, as well as healthy volunteers. The go…
Sponsor: Truway Health, Inc. • Aim: Diagnosis
Last updated Sep 12, 2026 00:00 UTC
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New rapid test could speed up diagnosis of deadly blood clotting disorder
Diagnosis OngoingThis study is testing a new, faster blood test for diagnosing acquired thrombotic thrombocytopenic purpura (aTTP), a rare but life-threatening blood clotting disorder. The new test, called HemosIL AcuStar, will be compared to two existing tests in 500 patients from Spain and Port…
Sponsor: Fundación Española de Hematología y Hemoterapía • Aim: Diagnosis
Last updated Jun 27, 2026 09:04 UTC
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10,000 patient records probed to unravel Sepsis-Clot mystery
Knowledge-focused OngoingThis study examines medical records from 10,000 people who had sepsis (blood poisoning) and developed dangerous blood clots (VTE) while in the ICU. Researchers want to see how many also had a serious blood disorder called DIC, which can cause clots throughout the body. By looking…
Sponsor: Bayer • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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AI takes on blood clotting: can ChatGPT guide surgeons on bleeding?
Knowledge-focused CancelledThis study evaluates whether artificial intelligence models can accurately interpret ROTEM blood clotting tests and recommend treatments for coagulopathy. Researchers will compare AI decisions to those of a panel of clinical experts using data from adults undergoing elective card…
Sponsor: Ondokuz Mayıs University • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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TTP Patients' hidden vessel damage revealed by advanced scans
Knowledge-focused OngoingThis study aims to measure damage to tiny blood vessels in people with thrombotic thrombocytopenic purpura (TTP), both during active disease and in remission. Researchers will use brain MRI, eye scans, and nailfold capillary exams to detect abnormalities. 79 participants will be …
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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COVID vaccine clot study scrapped before start
Knowledge-focused CancelledThis study aimed to collect medical information from people who developed unusual blood clots within four weeks of receiving a COVID-19 vaccine. The goal was to better understand any possible link between the vaccine and these rare events. However, the study was withdrawn before …
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Massive study tracks blood clot risks in 21,000 adults
Knowledge-focused OngoingThis study looks at what causes dangerous blood clots in the legs (venous thrombosis) and lungs (pulmonary embolism) in over 21,000 African American and white adults. Researchers are using data from two long-running heart health studies to find patterns and risk factors. The goal…
Sponsor: University of Minnesota • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Could a simple blood test prevent repeated miscarriages?
Knowledge-focused OngoingThis study aims to find out how often a blood clotting disorder called thrombophilia is the cause of recurrent pregnancy loss. Researchers will review the medical records of 1,000 women aged 18-40 who have had two or more miscarriages. The goal is to improve awareness and help do…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:32 UTC